Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3579800..3580399 Replicon chromosome
Accession NZ_CP076677
Organism Rhodopseudomonas palustris strain PP803

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KQX63_RS16430 Protein ID WP_263988875.1
Coordinates 3579800..3580084 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KQX63_RS16435 Protein ID WP_263988876.1
Coordinates 3580097..3580399 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQX63_RS16405 (KQX63_16330) 3574860..3575147 + 288 WP_263988871.1 hypothetical protein -
KQX63_RS16410 (KQX63_16335) 3575212..3576021 - 810 WP_263988872.1 DUF1295 domain-containing protein -
KQX63_RS16415 (KQX63_16340) 3576128..3576676 - 549 WP_263988873.1 hypothetical protein -
KQX63_RS16420 (KQX63_16345) 3576764..3578497 - 1734 WP_263988874.1 bifunctional protein-serine/threonine kinase/phosphatase -
KQX63_RS16425 (KQX63_16350) 3578567..3579406 - 840 WP_119019168.1 formate/nitrite transporter family protein -
KQX63_RS16430 (KQX63_16355) 3579800..3580084 + 285 WP_263988875.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KQX63_RS16435 (KQX63_16360) 3580097..3580399 + 303 WP_263988876.1 HigA family addiction module antitoxin Antitoxin
KQX63_RS16440 (KQX63_16365) 3580578..3581435 - 858 WP_263988877.1 SDR family oxidoreductase -
KQX63_RS16445 (KQX63_16370) 3581634..3583166 - 1533 WP_107345049.1 acyl-CoA carboxylase subunit beta -
KQX63_RS16450 (KQX63_16375) 3583444..3583860 + 417 WP_263988878.1 DUF4260 domain-containing protein -
KQX63_RS16455 (KQX63_16380) 3583864..3584138 - 275 Protein_3256 EscU/YscU/HrcU family type III secretion system export apparatus switch protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-94)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-83)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10555.21 Da        Isoelectric Point: 10.6525

>T206193 WP_263988875.1 NZ_CP076677:3579800-3580084 [Rhodopseudomonas palustris]
MIQSFRGKFARAILQDRKAPKGLPADLLGTARRKLVQLNAAAALADLAIPPGNRLEALRGDLQGLHSIRINDQWRIVFRW
KDTGPEDVEIVDYH

Download         Length: 285 bp

>T206193 NZ_CP102186:c5345219-5344836 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11271.00 Da        Isoelectric Point: 8.9759

>AT206193 WP_263988876.1 NZ_CP076677:3580097-3580399 [Rhodopseudomonas palustris]
MTKKLSPVHPGEILREEFLLPMNLSPYAVAAACGVPRTRIERLARQETPVTADTALRLAKYFGTTPNFWMNIQAQYDLEV
AEDNSADELRRIKPIKSRAA

Download         Length: 303 bp

>AT206193 NZ_CP102186:c5345461-5345219 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References