Detailed information of TA system TA206192

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4628432..4629027
• Replicon: chromosome
• Accession: NZ_CP076676
• Organism: Rhodopseudomonas palustris strain TLS06

Toxin (Protein)

• Gene name: graT
• Uniprot ID: B3Q7W1
• Locus tag: KQX62_RS21505
• Protein ID: WP_012497552.1
• Coordinates: 4628432..4628710 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KQX62_RS21510
• Protein ID: WP_012497553.1
• Coordinates: 4628722..4629027 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQX62_RS21495 (KQX62_21400)	4624834..4625190	-	357	WP_264074590.1	hypothetical protein	-
KQX62_RS21500 (KQX62_21405)	4625308..4628373	+	3066	WP_264074591.1	excinuclease ABC subunit UvrB	-
KQX62_RS21505 (KQX62_21410)	4628432..4628710	+	279	WP_012497552.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KQX62_RS21510 (KQX62_21415)	4628722..4629027	+	306	WP_012497553.1	HigA family addiction module antitoxin	Antitoxin
KQX62_RS21515 (KQX62_21420)	4629071..4629316	+	246	WP_263989641.1	transcriptional regulator	-
KQX62_RS21520 (KQX62_21425)	4629331..4629651	-	321	WP_264074592.1	(2Fe-2S) ferredoxin domain-containing protein	-
KQX62_RS21525 (KQX62_21430)	4629766..4631019	-	1254	WP_264074593.1	acetyl-CoA C-acetyltransferase	-
KQX62_RS21530 (KQX62_21435)	4631233..4631688	+	456	WP_264074594.1	hypothetical protein	-
KQX62_RS21535 (KQX62_21440)	4632171..4632602	+	432	WP_107345925.1	nuclear transport factor 2 family protein	-
KQX62_RS21540 (KQX62_21445)	4632810..4633250	+	441	WP_107345926.1	hypothetical protein	-
KQX62_RS21545 (KQX62_21450)	4633392..4633538	-	147	WP_199851768.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Cro/C1-type helix-turn-helix domain (17-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10913.43 Da
• Isoelectric Point: 9.0805

>T206192 WP_012497552.1 NZ_CP076676:4628432-4628710 [Rhodopseudomonas palustris]
MIRSFRNPATARLFADEDVPRFRAIERQARRKLLLLDGAAKLDDLRQPPGNRLEALKGDRRGQYSIRINDQWRICFEWRE
DGAEMVEIVDYH

Nucleotide

• Length: 279 bp

>T206192 NZ_CP102186:c5031814-5030897 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11312.14 Da
• Isoelectric Point: 10.2943

>AT206192 WP_012497553.1 NZ_CP076676:4628722-4629027 [Rhodopseudomonas palustris]
MAKPKQLPPIPPGEILIEEFMRPNGISQNRLARDIDINPARVNDIVHGRSAITAAVALRLAKYFGTTPELWMNLQASYDL
RRARAADWPAIEPRVRVLAAE

Nucleotide

• Length: 306 bp

>AT206192 NZ_CP102186:c5032578-5031820 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGTCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Structures

Toxin

• AlphaFold DB: A0A2R4GZL3