Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2197126..2197649 Replicon chromosome
Accession NZ_CP076660
Organism Staphylococcus aureus strain SG511 Berlin

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2W3LFI1
Locus tag KQU62_RS11035 Protein ID WP_000074047.1
Coordinates 2197126..2197392 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag KQU62_RS11040 Protein ID WP_000587617.1
Coordinates 2197392..2197649 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQU62_RS11015 (2192336) 2192336..2193523 - 1188 WP_000026190.1 MFS transporter -
KQU62_RS11020 (2193917) 2193917..2194693 - 777 WP_000072154.1 iron export ABC transporter permease subunit FetB -
KQU62_RS11025 (2194686) 2194686..2195348 - 663 WP_000923514.1 ATP-binding cassette domain-containing protein -
KQU62_RS11030 (2195694) 2195694..2196770 - 1077 WP_001076679.1 M42 family metallopeptidase -
KQU62_RS11035 (2197126) 2197126..2197392 - 267 WP_000074047.1 Txe/YoeB family addiction module toxin Toxin
KQU62_RS11040 (2197392) 2197392..2197649 - 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KQU62_RS11045 (2198009) 2198009..2198464 + 456 WP_123090023.1 DUF1307 domain-containing protein -
KQU62_RS11050 (2198632) 2198632..2200209 - 1578 WP_000143489.1 FMN-binding glutamate synthase family protein -
KQU62_RS11055 (2200405) 2200405..2201154 + 750 WP_000072447.1 CPBP family lipoprotein N-acylation protein LnsB -
KQU62_RS11060 (2201378) 2201378..2202571 - 1194 WP_000675407.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10662.26 Da        Isoelectric Point: 10.1384

>T206182 WP_000074047.1 NZ_CP076660:c2197392-2197126 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRIVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T206182 NZ_CP102182:c3503583-3503170 [Ralstonia solanacearum]
ATGCCCGCGACTGAGGCATTCTTCGACAGCAATGTCGTGCTGTACCTGCTGTCGGCCGACACCGCCAAGGCCGATGCGAC
GGAAACGCTGCTGATGACCGGCGGTGTCGTCAGCGTACAGGTACTGAACGAAACGACGCACGTGATGCGCCGCAAGCTGG
CCATGCCGTGGCACGCGATCGAAACGGTGCAGGAGGCCGTGCGTGCGCAATGCCGGGTCGAGCCGCTGACGCTCGAAACC
CATGATCTCGGACGGCGTATCGCAGAACGCTACGGATTGTCGGTCTATGACGCACTGATCGTCGCGGCGGCATTGCTTGC
CGGCTGCAACGTTCTGTATTCCGAGGATATGCAGCACGGCCTGGTGATCGAGCAGCATCTGCGCATCGTCAATCCTTTTC
CGGCACGGGCATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT206182 WP_000587617.1 NZ_CP076660:c2197649-2197392 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT206182 NZ_CP102182:c3503803-3503570 [Ralstonia solanacearum]
ATGCAAGTCTCGAAATGGGGCAACAGCCTCGCTATCCGGCTGCCGGCGGCCGTTGTGGAGGCGCTTCAGCTGCACGAAGG
CGACGACGTCGAGGTGGTGATCGCGGGCGAGCGCTCGTTTGGCGTCCGCCGCAAGCGCGCTGCGCGCGAGCTTTTCGACC
GGATCCACCAATATCGCGGCAAGCTGCCCGCCGATTTCATCTTCGAGCGCGACCAGGCCAATGCCCGCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W3LFI1

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References