Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2483934..2484118 Replicon chromosome
Accession NC_002953
Organism Staphylococcus aureus subsp. aureus MSSA476

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag SAS_RS12625 Protein ID WP_000482647.1
Coordinates 2484011..2484118 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2483934..2483994 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAS_RS12600 2479408..2479575 - 168 WP_001790576.1 hypothetical protein -
SAS_RS12610 2479806..2481539 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
SAS_RS12615 2481564..2483327 - 1764 WP_001064816.1 ABC transporter ATP-binding protein/permease -
- 2483934..2483994 + 61 - - Antitoxin
SAS_RS12625 2484011..2484118 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
SAS_RS12630 2484252..2484638 - 387 WP_000779360.1 flippase GtxA -
SAS_RS12635 2484896..2486038 + 1143 WP_001176871.1 glycerate kinase -
SAS_RS12640 2486098..2486757 + 660 WP_000831301.1 membrane protein -
SAS_RS12645 2486939..2488150 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
SAS_RS12650 2488273..2488746 - 474 WP_000456497.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T20618 WP_000482647.1 NC_002953:c2484118-2484011 [Staphylococcus aureus subsp. aureus MSSA476]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T20618 NC_002953:c2484118-2484011 [Staphylococcus aureus subsp. aureus MSSA476]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT20618 NC_002953:2483934-2483994 [Staphylococcus aureus subsp. aureus MSSA476]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References