Detailed information of TA system TA206172

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1708627..1708934
• Replicon: chromosome
• Accession: NZ_CP076660
• Organism: Staphylococcus aureus strain SG511 Berlin

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: KQU62_RS08490
• Protein ID: WP_011447039.1
• Coordinates: 1708758..1708934 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1708627..1708766 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQU62_RS08450 (1703966)	1703966..1704226	+	261	WP_001791826.1	hypothetical protein	-
KQU62_RS08455 (1704279)	1704279..1704629	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
KQU62_RS08460 (1705314)	1705314..1705763	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
KQU62_RS08465 (1705858)	1705858..1706193	-	336	Protein_1636	SH3 domain-containing protein	-
KQU62_RS08470 (1706843)	1706843..1707334	-	492	WP_000919350.1	staphylokinase	-
KQU62_RS08475 (1707525)	1707525..1708280	-	756	WP_000861038.1	CHAP domain-containing protein	-
KQU62_RS08480 (1708292)	1708292..1708546	-	255	WP_000611512.1	phage holin	-
KQU62_RS08485 (1708598)	1708598..1708705	+	108	WP_001791821.1	hypothetical protein	-
- (1708627)	1708627..1708766	+	140	NuclAT_0	-	Antitoxin
- (1708627)	1708627..1708766	+	140	NuclAT_0	-	Antitoxin
- (1708627)	1708627..1708766	+	140	NuclAT_0	-	Antitoxin
- (1708627)	1708627..1708766	+	140	NuclAT_0	-	Antitoxin
KQU62_RS08490 (1708758)	1708758..1708934	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
KQU62_RS08495 (1709084)	1709084..1709380	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
KQU62_RS08500 (1709438)	1709438..1709725	-	288	WP_001040261.1	hypothetical protein	-
KQU62_RS08505 (1709772)	1709772..1709924	-	153	WP_001153681.1	hypothetical protein	-
KQU62_RS08510 (1709914)	1709914..1713699	-	3786	WP_000582165.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	1704279..1757629	53350

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T206172 WP_011447039.1 NZ_CP076660:c1708934-1708758 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T206172 NZ_CP102179:1098514-1098858 [Pseudomonas canavaninivorans]
ATGCGAACCTTATTTTTTGAAACGACTACGTTCACTGCCACGGTTGGCCATTACCTGACCGATGATGAATATCGCCTGCT
TCAGTTCTATATGCAGCAGCATCCAGAGGCCGGTGACGTCATGCCACGTACCGGTGGCTTCCGTAAGCTGCGTTGGTTCG
ATGAGCGTCGTGGCAAAGGGAAGCGAGGTGGGCTGCGGGTCATTTATTATTGGTTGAGGCATGATCGTCAGTTCTGGATG
TTTGCGATTTATGACAAGGACGAACTGGAAAACCTGACCTCCGAGCAAGAGAAGACGCTTAAGCGCGCCATAGAAGCTGA
GTTGAAAGTACGAGGTACCTTATGA

Antitoxin

Nucleotide

• Length: 140 bp

>AT206172 NZ_CP076660:1708627-1708766 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin