Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2458576..2459093 Replicon chromosome
Accession NC_002953
Organism Staphylococcus aureus subsp. aureus MSSA476

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag SAS_RS12470 Protein ID WP_000113262.1
Coordinates 2458576..2458842 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag SAS_RS12475 Protein ID WP_000584499.1
Coordinates 2458842..2459093 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAS_RS12445 2454001..2454528 - 528 WP_000973468.1 GNAT family N-acetyltransferase -
SAS_RS12450 2454772..2455596 - 825 WP_000572040.1 formate/nitrite transporter family protein -
SAS_RS12455 2455813..2455995 - 183 WP_000230294.1 hypothetical protein -
SAS_RS12460 2456079..2456546 - 468 WP_000153344.1 SRPBCC domain-containing protein -
SAS_RS12465 2456732..2458282 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
SAS_RS12470 2458576..2458842 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
SAS_RS12475 2458842..2459093 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SAS_RS12480 2459258..2459359 - 102 Protein_2354 hypothetical protein -
SAS_RS12485 2459366..2459965 - 600 WP_000162810.1 DsbA family protein -
SAS_RS12490 2459984..2460346 - 363 WP_000819843.1 DUF4467 domain-containing protein -
SAS_RS12495 2460601..2461851 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
SAS_RS12500 2461948..2462679 - 732 WP_000615458.1 amino acid ABC transporter ATP-binding protein -
SAS_RS12505 2462676..2463395 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T20617 WP_000113262.1 NC_002953:c2458842-2458576 [Staphylococcus aureus subsp. aureus MSSA476]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T20617 NC_002953:c2458842-2458576 [Staphylococcus aureus subsp. aureus MSSA476]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAAATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT20617 WP_000584499.1 NC_002953:c2459093-2458842 [Staphylococcus aureus subsp. aureus MSSA476]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT20617 NC_002953:c2459093-2458842 [Staphylococcus aureus subsp. aureus MSSA476]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References