Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2066330..2067090 Replicon chromosome
Accession NZ_CP076656
Organism Pasteurella sp. XG20

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KPF51_RS09695 Protein ID WP_061406326.1
Coordinates 2066764..2067090 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KPF51_RS09690 Protein ID WP_005757699.1
Coordinates 2066330..2066656 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPF51_RS09670 (KPF51_09670) 2061766..2062797 + 1032 WP_061406329.1 hypothetical protein -
KPF51_RS09675 (KPF51_09675) 2063033..2064043 + 1011 WP_061406328.1 hypothetical protein -
KPF51_RS09680 (KPF51_09680) 2064106..2064696 + 591 WP_061406438.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
KPF51_RS09685 (KPF51_09685) 2064755..2066275 + 1521 WP_061406327.1 surface lipoprotein assembly modifier -
KPF51_RS09690 (KPF51_09690) 2066330..2066656 - 327 WP_005757699.1 HigA family addiction module antitoxin Antitoxin
KPF51_RS09695 (KPF51_09695) 2066764..2067090 - 327 WP_061406326.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KPF51_RS09700 (KPF51_09700) 2067248..2067724 + 477 WP_042742721.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
KPF51_RS09705 (KPF51_09705) 2067798..2068667 - 870 WP_061406325.1 VirK/YbjX family protein -
KPF51_RS09710 (KPF51_09710) 2068778..2069395 + 618 WP_005724253.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
KPF51_RS09715 (KPF51_09715) 2069504..2071033 + 1530 WP_061406324.1 YifB family Mg chelatase-like AAA ATPase -
KPF51_RS09720 (KPF51_09720) 2071087..2071773 - 687 WP_061406323.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(12-104)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-102)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12923.75 Da        Isoelectric Point: 9.6705

>T206166 WP_061406326.1 NZ_CP076656:c2067090-2066764 [Pasteurella sp. XG20]
MDRVRFNLTEDSFQDKYLYEYFLYGSKHKNIPSDIENTLAHKLDMLDSANTLSDLRSQPGNKLEKLEPKTSGLYSIRVNV
KYRLIFKYKESNFPKITELRLDKHQYRL

Download         Length: 327 bp

>T206166 NZ_CP102177:c4647676-4647389 [Pseudomonas corrugata]
ATGGCCGTTGAGTACGGAGTCGAGTGGGATCCGAAGGCGCTGAAAGAACTGCGAAAGCTCGACGGCGCCATCCGCCTCCA
GTTCTTGCGAAAGCTCCAAGAGCGGCAGGCCGCGCCACGAGTGCCAGGTGATGCACTTCACGGCATGAAGGATTGCTACA
AGATCAAATTACGCGGCGCTGGTTACCGGCTTGTATACCGTGTTGAGGATAAAAGGATTGTCATCCTGGTGCTGGCAGTA
GGCAAGCGGGAACGAAGCAGCGTTTACAATTCGGCCAAGAGTCGGTAG

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12377.41 Da        Isoelectric Point: 7.2034

>AT206166 WP_005757699.1 NZ_CP076656:c2066656-2066330 [Pasteurella sp. XG20]
MSRVQRKPSTVGDILLDEYLVPLNLKIADLATMLDVHRNTASALVNNNTKLSLEMALKLAKLFNTSPEFWLNLQMKLDLW
EIENNARFQESLKKISSIDQHNLLEKIA

Download         Length: 327 bp

>AT206166 NZ_CP102177:c4647953-4647666 [Pseudomonas corrugata]
ATGCAAAACATTCTGGCCGATGTGGCCGTCAGCGTATCCGAGCTCAAGAAGAACCCCTCATCCGTCTTAAACGGTGCCAA
CGGCTTGCCCGTGGCCGTACTGAACCACAACCGAGTTATGGGCTACATGGTTCCGGCGAACGTCTACGAAGCGATGGTCG
AGCGCCTGGACGAATTGGAGCTCGTCCAACTGGTCAAGGCACGGCTCGACGCCAACGAAACACCTGTTCGAGTATCTCTC
AACGATCTCATTGGCGAGGCCGAGGCAGATATCGCCAATGGCCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References