Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2205473..2205689 Replicon chromosome
Accession NC_002953
Organism Staphylococcus aureus subsp. aureus MSSA476

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag SAS_RS11145 Protein ID WP_001802298.1
Coordinates 2205585..2205689 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2205473..2205528 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAS_RS11125 2201676..2202341 - 666 WP_001024095.1 SDR family oxidoreductase -
SAS_RS11130 2202493..2202813 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
SAS_RS11135 2202815..2203795 + 981 WP_000019743.1 CDF family zinc efflux transporter CzrB -
SAS_RS11140 2204061..2205152 + 1092 WP_000495683.1 hypothetical protein -
- 2205473..2205528 + 56 - - Antitoxin
SAS_RS11145 2205585..2205689 - 105 WP_001802298.1 hypothetical protein Toxin
SAS_RS14835 2206369..2206527 + 159 WP_001792784.1 hypothetical protein -
SAS_RS11150 2207186..2208043 - 858 WP_000370917.1 Cof-type HAD-IIB family hydrolase -
SAS_RS11155 2208111..2208893 - 783 WP_000908178.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T20614 WP_001802298.1 NC_002953:c2205689-2205585 [Staphylococcus aureus subsp. aureus MSSA476]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T20614 NC_002953:c2205689-2205585 [Staphylococcus aureus subsp. aureus MSSA476]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 56 bp

>AT20614 NC_002953:2205473-2205528 [Staphylococcus aureus subsp. aureus MSSA476]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References