Detailed information of TA system TA206119

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1191545..1192275
• Replicon: chromosome
• Accession: NZ_CP076651
• Organism: Serratia ureilytica strain S24

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A8B4GR63
• Locus tag: KQJ82_RS05580
• Protein ID: WP_004937033.1
• Coordinates: 1191545..1191856 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KQJ82_RS05585
• Protein ID: WP_033644489.1
• Coordinates: 1191853..1192275 (+)
• Length: 141 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQJ82_RS05550 (KQJ82_05550)	1186860..1187585	+	726	WP_004937040.1	LPS export ABC transporter ATP-binding protein	-
KQJ82_RS05555 (KQJ82_05555)	1187638..1189071	+	1434	WP_004937039.1	RNA polymerase factor sigma-54	-
KQJ82_RS05560 (KQJ82_05560)	1189095..1189382	+	288	WP_004937038.1	ribosome hibernation promoting factor	-
KQJ82_RS05565 (KQJ82_05565)	1189538..1189999	+	462	WP_016930212.1	PTS IIA-like nitrogen regulatory protein PtsN	-
KQJ82_RS05570 (KQJ82_05570)	1190127..1190981	+	855	WP_015379177.1	RNase adapter RapZ	-
KQJ82_RS05575 (KQJ82_05575)	1190978..1191250	+	273	WP_004937034.1	PTS phosphocarrier protein NPr	-
KQJ82_RS05580 (KQJ82_05580)	1191545..1191856	+	312	WP_004937033.1	type II toxin-antitoxin system HigB family toxin	Toxin
KQJ82_RS05585 (KQJ82_05585)	1191853..1192275	+	423	WP_033644489.1	helix-turn-helix domain-containing protein	Antitoxin
KQJ82_RS05590 (KQJ82_05590)	1192282..1194198	-	1917	WP_033644486.1	PRD domain-containing protein	-
KQJ82_RS05595 (KQJ82_05595)	1194250..1195464	-	1215	WP_046687876.1	lactonase family protein	-
KQJ82_RS05600 (KQJ82_05600)	1195552..1196292	-	741	WP_046687877.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (20-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (81-135)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12289.14 Da
• Isoelectric Point: 10.0957

>T206119 WP_004937033.1 NZ_CP076651:1191545-1191856 [Serratia ureilytica]
MHIISREPFNNATKQYPNEATALEAIYKALRRGEFRTPDELKALFPSLDRMKYKEKWWVIDVGGNHLRILFFASFETQKV
FIKHIVSHAEYDKLMQHYRRSSS

Nucleotide

• Length: 312 bp

>T206119 NZ_CP102143:c1508704-1508444 [Streptococcus suis]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTAAGAAATTAGATAGGCAAATTCAGAGGTTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin

Protein

• Length: 141 a.a.
• Molecular weight: 15784.13 Da
• Isoelectric Point: 5.2139

>AT206119 WP_033644489.1 NZ_CP076651:1191853-1192275 [Serratia ureilytica]
MITDAIKAADALLRAVPLLQGSHAQQDYREALELVEYLLENDERHPLIDMLAKKIAEYEDNSAEFTAFNQRIAQLPQGVA
ALRVLMEQHQLSQSDFEHEIGKKSLVNQILNGKRSLTIPHIMALAKRFNLPPALFLPEAD

Nucleotide

• Length: 423 bp

>AT206119 NZ_CP102143:c1508927-1508706 [Streptococcus suis]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Structures

Toxin

• AlphaFold DB: A0A8B4GR63