Detailed information of TA system TA206116

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 798853..799505
• Replicon: chromosome
• Accession: NZ_CP076651
• Organism: Serratia ureilytica strain S24

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: KQJ82_RS03755
• Protein ID: WP_089195112.1
• Coordinates: 798853..799197 (+)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A8B4GZD7
• Locus tag: KQJ82_RS03760
• Protein ID: WP_038878665.1
• Coordinates: 799203..799505 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQJ82_RS03740 (KQJ82_03740)	794646..795200	+	555	WP_046687732.1	hypothetical protein	-
KQJ82_RS03745 (KQJ82_03745)	795172..797454	-	2283	WP_196018848.1	molybdopterin guanine dinucleotide-containing S/N-oxide reductase	-
KQJ82_RS03750 (KQJ82_03750)	797675..798694	+	1020	WP_033652132.1	HTH-type transcriptional regulator GalR	-
KQJ82_RS03755 (KQJ82_03755)	798853..799197	+	345	WP_089195112.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KQJ82_RS03760 (KQJ82_03760)	799203..799505	+	303	WP_038878665.1	XRE family transcriptional regulator	Antitoxin
KQJ82_RS03765 (KQJ82_03765)	799533..800795	-	1263	WP_033644838.1	diaminopimelate decarboxylase	-
KQJ82_RS03770 (KQJ82_03770)	800929..801852	+	924	WP_047026615.1	LysR family transcriptional regulator	-
KQJ82_RS03775 (KQJ82_03775)	801880..802788	-	909	WP_033644836.1	LysR family transcriptional regulator	-
KQJ82_RS03780 (KQJ82_03780)	802897..803781	+	885	WP_047026616.1	MBL fold metallo-hydrolase	-
KQJ82_RS03785 (KQJ82_03785)	803850..804497	+	648	WP_216701515.1	DsbA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-104)

Antitoxin

• HigA2-like, helix-turn-helix domain (30-89)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 13353.38 Da
• Isoelectric Point: 10.9964

>T206116 WP_089195112.1 NZ_CP076651:798853-799197 [Serratia ureilytica]
MWQVVTVERFDDWFLALNNAQQTSILAAIFKLQTFGPQLARPHADTLHFSDAARQLRELRVQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Nucleotide

• Length: 345 bp

>T206116 NZ_CP102143:510019-510288 [Streptococcus suis]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11111.04 Da
• Isoelectric Point: 10.3986

>AT206116 WP_038878665.1 NZ_CP076651:799203-799505 [Serratia ureilytica]
MAKPLSQLIDKLDPAVVATARQKADKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Nucleotide

• Length: 303 bp

>AT206116 NZ_CP102143:509802-510029 [Streptococcus suis]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GZD7