Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 64892..65552 Replicon chromosome
Accession NZ_CP076651
Organism Serratia ureilytica strain S24

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KQJ82_RS00310 Protein ID WP_089194950.1
Coordinates 65199..65552 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8G2G5Z5
Locus tag KQJ82_RS00305 Protein ID WP_016927038.1
Coordinates 64892..65194 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQJ82_RS00285 (KQJ82_00285) 60495..61409 - 915 WP_033643752.1 branched-chain amino acid ABC transporter permease -
KQJ82_RS00290 (KQJ82_00290) 61534..62652 - 1119 WP_016927040.1 branched-chain amino acid ABC transporter substrate-binding protein -
KQJ82_RS00300 (KQJ82_00300) 63258..64466 - 1209 WP_123061821.1 aldose 1-epimerase family protein -
KQJ82_RS00305 (KQJ82_00305) 64892..65194 - 303 WP_016927038.1 XRE family transcriptional regulator Antitoxin
KQJ82_RS00310 (KQJ82_00310) 65199..65552 - 354 WP_089194950.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KQJ82_RS00315 (KQJ82_00315) 65991..67286 + 1296 WP_196018657.1 MFS transporter -
KQJ82_RS00320 (KQJ82_00320) 67313..68119 + 807 WP_033643757.1 substrate-binding domain-containing protein -
KQJ82_RS00325 (KQJ82_00325) 68094..68993 - 900 WP_033643758.1 LysR family transcriptional regulator -
KQJ82_RS00330 (KQJ82_00330) 69096..69461 - 366 WP_033643759.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13532.47 Da        Isoelectric Point: 9.0587

>T206115 WP_089194950.1 NZ_CP076651:c65552-65199 [Serratia ureilytica]
VWEIKTTDAFDHWFRSLSDADRAGVLAALMVLREKGPGLPRPYADTVKGSRYSNMKELRIQCRGEPLRAFFAFDPYRIGI
VLCAGNKAGNEKRFYDRMIQVADREFTNWLNTLNEKE

Download         Length: 354 bp

>T206115 NZ_CP102141:c2115836-2115507 [Streptococcus suis]
ATGGAATTTGAGTCATATTCAGTGATACTTGCTCCAGCAGTGGAGAGGGAATTGGCAGCTATTTACGCCTATTTCTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTCCAAGCTTTGGAGAGTTTGCAAATTTTTCCTGAAC
GTGGCTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCACATCTAACCCGAGGTTACGTTATTGGAAAAGAC
TACATCGCCCTCTATCGCGTAGTGAAAAATGAAGTTCGAGTGGGTCACCTTTTTGCGACCAAGAGTGATTATGTGAAGTT
GTTGAAGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11093.96 Da        Isoelectric Point: 6.4738

>AT206115 WP_016927038.1 NZ_CP076651:c65194-64892 [Serratia ureilytica]
MGRTLEQLIADEKPEVVAKAQALAADIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDIELPDGSHYEFVL

Download         Length: 303 bp

>AT206115 NZ_CP102141:c2116113-2115826 [Streptococcus suis]
TTGATAACTATAAAGAAGGATGCCCAAGTAAATTTTAAAACTGATTCCAGACTTTTAGAAAAAGCCAAGGAAGTATTTGC
TATGAACCAGCTGGATTTGACTGCTGGTTTTAACCTCTTCTTGCAAAATATCGCTGTAAAAAATGAGTTGCCAATTCTGA
CTGAAGAAGAGTTGGAAAGAGAAGAGTTGTTTTTACAGCTTCAGAAGGAAATCCAGGAAAACCAACAGGCGATTGAGGCA
GGTCAAGGGATCAGCCTAGAAAGTGTCAAAGAGAAGTATGGAATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References