Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 684780..685473 Replicon chromosome
Accession NZ_CP076646
Organism Escherichia coli strain GD33

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag KP013_RS03355 Protein ID WP_000415584.1
Coordinates 684780..685076 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KP013_RS03360 Protein ID WP_000650107.1
Coordinates 685078..685473 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP013_RS03320 (679868) 679868..680182 - 315 WP_000958598.1 putative quinol monooxygenase -
KP013_RS03325 (680213) 680213..680794 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
KP013_RS03330 (681113) 681113..681445 + 333 WP_000917684.1 DUF2645 family protein -
KP013_RS03335 (681491) 681491..682840 - 1350 WP_001618857.1 quorum sensing histidine kinase QseC -
KP013_RS03340 (682837) 682837..683496 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
KP013_RS03345 (683648) 683648..684040 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
KP013_RS03350 (684093) 684093..684575 + 483 WP_000183505.1 GyrI-like domain-containing protein -
KP013_RS03355 (684780) 684780..685076 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
KP013_RS03360 (685078) 685078..685473 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KP013_RS03365 (685606) 685606..687213 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
KP013_RS03370 (687351) 687351..689609 + 2259 WP_049253102.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T206088 WP_000415584.1 NZ_CP076646:684780-685076 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T206088 NZ_CP102136:724337-724519 [Streptococcus suis]
ATGCCTATGACACAAAAAGAAATGGTTAAGCTACTTACCGCCCATGGTTGGACAAAAACCAAAGGCGGTAAGGGGTCACA
CGTGAAACTTGAAAAAGCAGGCGAGCGACCTATAACCATTCCCCACGGTGAAATAAACAAATACACCGAAAGGGGTATCA
AAAAGCAAGCAGGGCTGTTATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT206088 WP_000650107.1 NZ_CP076646:685078-685473 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT206088 NZ_CP102136:724557-725006 [Streptococcus suis]
ATGCTTGTCACTTATCCAGCTTTATTTTATTTTGATGATACAGACGGAGCTAACGCCCCTTACTTTGTAACTTTCCCTGA
TTTTGAGCATTCAGCAACTCAAGGCGAGGATATGGCGGACGCTATGGCAATGGCTAGCGATTGGTTAGGCATGAACTTAG
CTGATTATATCGAGAATGGAAGAGACATTCCTACCCCGTCTTCTATAAACACTTTGTCATTAGTAGATAATAACCCTTTC
CGTAATGAGGATTTTGAGATGGTTTACGATTCTAGCAAGTCTTTTATCTCCATGGTGATGGTGGACGTTGCAAAGTATTT
GGGCAGTCAAGAGCCAGTAAAGAAAACACTCACTATCCCACGCTGGGCAGATACTCTAGGACGTGAACTAGGATTGAATT
TCTCACAGACCCTCACGGATGCAATTGCAGATAAAAAAATTCATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References