Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 620205..620932 | Replicon | chromosome |
| Accession | NZ_CP076646 | ||
| Organism | Escherichia coli strain GD33 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A5P0J3S6 |
| Locus tag | KP013_RS03050 | Protein ID | WP_063501682.1 |
| Coordinates | 620205..620519 (+) | Length | 105 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | KP013_RS03055 | Protein ID | WP_000560266.1 |
| Coordinates | 620516..620932 (+) | Length | 139 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KP013_RS03030 (616363) | 616363..617349 | - | 987 | WP_000617698.1 | Gfo/Idh/MocA family oxidoreductase | - |
| KP013_RS03035 (617428) | 617428..618120 | - | 693 | WP_063501683.1 | vancomycin high temperature exclusion protein | - |
| KP013_RS03040 (618197) | 618197..618700 | - | 504 | WP_001333820.1 | M48 family metallopeptidase | - |
| KP013_RS03045 (618785) | 618785..619921 | + | 1137 | WP_000018695.1 | 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG | - |
| KP013_RS03050 (620205) | 620205..620519 | + | 315 | WP_063501682.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| KP013_RS03055 (620516) | 620516..620932 | + | 417 | WP_000560266.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| KP013_RS03060 (620977) | 620977..622995 | - | 2019 | WP_000121433.1 | NADPH-dependent 2,4-dienoyl-CoA reductase | - |
| KP013_RS03065 (623421) | 623421..625772 | - | 2352 | WP_071447716.1 | alpha-glucosidase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 12202.24 Da Isoelectric Point: 10.1604
>T206087 WP_063501682.1 NZ_CP076646:620205-620519 [Escherichia coli]
MHLITQKALKDAAEKYPQHKTELVALRNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK
MHLITQKALKDAAEKYPQHKTELVALRNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK
Download Length: 315 bp
>T206087 NZ_CP102136:298683-299468 [Streptococcus suis]
ATGAGGTTGGAAGAATTCAGTGAGGCTGGGTTTCAGAAGGCCTTACAGCGAACCATTCGGGCCTTAACCCGAGGAAAGAC
GATTCCAGGTCAACCGAAAGCTATCTTGCTTGGTGGACAAAGCGGAGCAGGTAAGACGACTATTCATCGTATCAAGCAAA
AAGAATTTCAAGGCAATATCATTATCATCGATGGTGATAGCTACCGTTCTCAGCATCCCAACTACTTAGCCCTGCAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTGGTTGACGAACTCAGCAC
GCAGGGTTATCACTTGCTGATTGAGGGAACTTTGCGAACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTAGTATCTA
AAGGCTACCAGGTTTCCTTAGCTGTGATTGGCACCAAACCAGAATTGTCCTATCTCAGTACTTTGATTCGTTACGAAGAG
CTTTATGCCATCGATCCCAATCAGGCCAGAGCAACGCCAAAAGAACACCATGATGGGATTGTAGAGAACTTGGTTGATAA
CCTAAGGGAGTTAGAAAGAGAGCAACTCTTTGACCAGATTCAGATTTATCAAAGAGACAGGACTTGCATTTATGATTCTA
AAACGGATGATGGTTCTGCAGCAGAAGTTCTTCAAAATTGCCTTTTCGGAGAGTGGAGTAAAGTAGAGGAGGAGATGTTT
AAGATGGGGCAGGAACGGTTGAGGGAGTTGAGTAAAAGTAATGGAAACGATGTATTGATGAGTTAG
ATGAGGTTGGAAGAATTCAGTGAGGCTGGGTTTCAGAAGGCCTTACAGCGAACCATTCGGGCCTTAACCCGAGGAAAGAC
GATTCCAGGTCAACCGAAAGCTATCTTGCTTGGTGGACAAAGCGGAGCAGGTAAGACGACTATTCATCGTATCAAGCAAA
AAGAATTTCAAGGCAATATCATTATCATCGATGGTGATAGCTACCGTTCTCAGCATCCCAACTACTTAGCCCTGCAAGAA
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTGGTTGACGAACTCAGCAC
GCAGGGTTATCACTTGCTGATTGAGGGAACTTTGCGAACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTAGTATCTA
AAGGCTACCAGGTTTCCTTAGCTGTGATTGGCACCAAACCAGAATTGTCCTATCTCAGTACTTTGATTCGTTACGAAGAG
CTTTATGCCATCGATCCCAATCAGGCCAGAGCAACGCCAAAAGAACACCATGATGGGATTGTAGAGAACTTGGTTGATAA
CCTAAGGGAGTTAGAAAGAGAGCAACTCTTTGACCAGATTCAGATTTATCAAAGAGACAGGACTTGCATTTATGATTCTA
AAACGGATGATGGTTCTGCAGCAGAAGTTCTTCAAAATTGCCTTTTCGGAGAGTGGAGTAAAGTAGAGGAGGAGATGTTT
AAGATGGGGCAGGAACGGTTGAGGGAGTTGAGTAAAAGTAATGGAAACGATGTATTGATGAGTTAG
Antitoxin
Download Length: 139 a.a. Molecular weight: 14995.42 Da Isoelectric Point: 4.4547
>AT206087 WP_000560266.1 NZ_CP076646:620516-620932 [Escherichia coli]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID
Download Length: 417 bp
>AT206087 NZ_CP102136:298207-298683 [Streptococcus suis]
ATGATCGGAGAAAATATAAAAACACTACGCCATACACATGATTTAACACAACCAGAATTTGCGAAAATGGTTGGTATTTC
ACGCAATAGCCTAAGTCGTTATGAAAATGGAACTAGTAAAATTTCAACAGAACTAATCGACCGTATTTGTCAAAAATTTA
ACGTTTCTTATGTCGACATTGTAGGGGAAGAGAAGATGTTAGCACCTGTTGAAGATTACCAACTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTATAGATACCAGGATAGTCAGAATATTGCTTTTGATGATGA
ATCGAATCCGTGGATTCTCATGAGTGATGACTTGGCCGAATTGATTAACACGAAAATTTACCTTGTCGATACTTTCGATG
AAATAGAGCGTTACAATGGCTATTTAGACGGTATCGAGCGGATGTTAGACATGGTGCATCATCGGGTGGTGGCTTAA
ATGATCGGAGAAAATATAAAAACACTACGCCATACACATGATTTAACACAACCAGAATTTGCGAAAATGGTTGGTATTTC
ACGCAATAGCCTAAGTCGTTATGAAAATGGAACTAGTAAAATTTCAACAGAACTAATCGACCGTATTTGTCAAAAATTTA
ACGTTTCTTATGTCGACATTGTAGGGGAAGAGAAGATGTTAGCACCTGTTGAAGATTACCAACTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTATAGATACCAGGATAGTCAGAATATTGCTTTTGATGATGA
ATCGAATCCGTGGATTCTCATGAGTGATGACTTGGCCGAATTGATTAACACGAAAATTTACCTTGTCGATACTTTCGATG
AAATAGAGCGTTACAATGGCTATTTAGACGGTATCGAGCGGATGTTAGACATGGTGCATCATCGGGTGGTGGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|