Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 719201..719894 Replicon chromosome
Accession NZ_CP076645
Organism Escherichia coli strain MSI001

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag KP725_RS03505 Protein ID WP_000415584.1
Coordinates 719201..719497 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KP725_RS03510 Protein ID WP_000650107.1
Coordinates 719499..719894 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP725_RS03470 (714289) 714289..714603 - 315 WP_000958598.1 putative quinol monooxygenase -
KP725_RS03475 (714634) 714634..715215 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
KP725_RS03480 (715534) 715534..715866 + 333 WP_000917684.1 DUF2645 family protein -
KP725_RS03485 (715912) 715912..717261 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
KP725_RS03490 (717258) 717258..717917 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
KP725_RS03495 (718069) 718069..718461 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
KP725_RS03500 (718514) 718514..718996 + 483 WP_000183505.1 GyrI-like domain-containing protein -
KP725_RS03505 (719201) 719201..719497 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
KP725_RS03510 (719499) 719499..719894 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KP725_RS03515 (720027) 720027..721634 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
KP725_RS03520 (721772) 721772..724030 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T206067 WP_000415584.1 NZ_CP076645:719201-719497 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T206067 NZ_CP102094:c1538086-1537904 [Streptococcus suis]
ATGCCTATGACACAAAAAGAAATGGTTAAGCTACTTACCGCCCATGGTTGGACAAAAACCAAAGGCGGTAAGGGGTCACA
CGTGAAACTTGAAAAAGCAGGCGAGCGACCTATAACCATTCCCCACGGTGAAATAAACAAATACACCGAAAGGGGTATCA
AAAAGCAAGCAGGGCTGTTATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT206067 WP_000650107.1 NZ_CP076645:719499-719894 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT206067 NZ_CP102094:c1537866-1537417 [Streptococcus suis]
ATGCTTGTCACTTATCCAGCTTTATTTTATTTTGATGATACAGACGGAGCTAACGCCCCTTACTTTGTAACTTTCCCTGA
TTTTGAGTATTCAGCAACTCAAGGCGAGGATATGGCGGACGCTATGGCAATGGCTAGCGATTGGTTAGGCATGAACTTAG
CTGATTATATCGAGAATGGAAGAGACATTCCTACCCCGTCTTCTATAAACACTTTGTCATTAGTAGATAATAACCCTTTC
CGTAATGAGGATTTTGAGATGGTTTACGATTCTAGCAAGTCTTTTATCTCCATGGTGATGGTGGACGTTGCAAAGTATTT
GGGCAGTCAAGAGCCAGTAAAGAAAACACTCACTATCCCACGCTGGGCAGACACTCTAGGACGTGAACTAGGATTGAATT
TCTCACAGACCCTCACGGATGCAATTGCAGATAAAAAAATTCATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References