Detailed information of TA system TA206064

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/HipA(toxin)
• Location: 2223415..2224772
• Replicon: chromosome
• Accession: NZ_CP076643
• Organism: Vibrio ostreae strain OG9-811

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: -
• Locus tag: KNV97_RS16315
• Protein ID: WP_256612159.1
• Coordinates: 2223726..2224772 (+)
• Length: 349 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: -
• Locus tag: KNV97_RS16305
• Protein ID: WP_218562346.1
• Coordinates: 2223415..2223645 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KNV97_RS16275 (KNV97_16275)	2218890..2219270	-	381	WP_218562343.1	hypothetical protein	-
KNV97_RS16280 (KNV97_16280)	2219343..2219753	+	411	WP_218562344.1	hypothetical protein	-
KNV97_RS16285 (KNV97_16285)	2220018..2220482	-	465	WP_213962883.1	hypothetical protein	-
KNV97_RS16290 (KNV97_16290)	2221187..2221522	+	336	WP_025631710.1	helix-turn-helix domain-containing protein	-
KNV97_RS16295 (KNV97_16295)	2221515..2222922	+	1408	Protein_1987	HipA domain-containing protein	-
KNV97_RS16300 (KNV97_16300)	2223110..2223430	+	321	WP_218562345.1	helix-turn-helix transcriptional regulator	-
KNV97_RS16305 (KNV97_16305)	2223415..2223645	+	231	WP_218562346.1	HipA N-terminal domain-containing protein	Antitoxin
KNV97_RS16315 (KNV97_16315)	2223726..2224772	+	1047	WP_256612159.1	HipA domain-containing protein	Toxin
KNV97_RS16325 (KNV97_16325)	2225031..2225795	-	765	WP_218562348.1	hypothetical protein	-
KNV97_RS16330 (KNV97_16330)	2225856..2226422	-	567	WP_218562349.1	DUF4145 domain-containing protein	-
KNV97_RS16335 (KNV97_16335)	2226461..2226898	-	438	WP_203534970.1	hypothetical protein	-
KNV97_RS16340 (KNV97_16340)	2227042..2227644	-	603	WP_218562350.1	hypothetical protein	-
KNV97_RS16345 (KNV97_16345)	2227759..2228331	-	573	WP_218562351.1	hypothetical protein	-
KNV97_RS16350 (KNV97_16350)	2228938..2229150	+	213	WP_047460531.1	cold-shock protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2196062..2240656	44594

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (60-309)

Antitoxin

• HipA, N-terminal subdomain 1 (5-70)

Sequences

Toxin

Protein

• Length: 349 a.a.
• Molecular weight: 39583.06 Da
• Isoelectric Point: 4.9580

>T206064 WP_256612159.1 NZ_CP076643:2223726-2224772 [Vibrio ostreae]
MYPSNRSLISLDELNEQNREQVEYKKGEIKTLLGSNRFQIQLPFSRTEFVTELPKKQKGMSISGYQPKLSLAINDENQLG
VVEDKALFILKPSPEEFPHLAENEHATMLVMKFLGFDTPPFGLVRFNDPDGEGELAFMIRRYDRLNAGEEAIHQEQLDAA
MAVREKYGKTEGDAEGYVSYEQACKFLIHQVDGSLNFKKELFNRILVAYFLGNNDLHLRNIGLLLPEQEATRLAPIYDYV
SIAPYPGYIANENPLALPLLASEEGDNFNTSGYQSHSTYTGYDFLTFAQNIGLKPKLATKMIQDLCAKQEAILDIYRNSF
MLPKHVEKVAEWILSRINYLGQLEHVAV

Nucleotide

• Length: 1047 bp

>T206064 NZ_CP102089:2006902-2007087 [Staphylococcus capitis subsp. capitis]
GTGAGTTTGCATTTTCAAATATTGTTATGGCTAGCAATTATATTTATTGTCGCTGGAGCTATTATTTTAACAATTATGCT
TAAGACTAAGAAAGAAGAAAGAAAAGAATCTTATTTAGGATTTACTGTAATATTCTTGATTTTTGGATTTGCTATGCTTA
TATACACACTCATTTTCGGGTTGTAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8715.08 Da
• Isoelectric Point: 8.9212

>AT206064 WP_218562346.1 NZ_CP076643:2223415-2223645 [Vibrio ostreae]
MDRKVKVLLYGKFCGVLSQNEQGYLFEYEPGYRGRSLSLSMPVEGGPFESKELHPFFLSLAPRRMAEEALLRTTKN

Nucleotide

• Length: 231 bp

>AT206064 NZ_CP102089:2006612-2006869 [Staphylococcus capitis subsp. capitis]
ATGAAAATATTTAGTATAAATGTGATTAATATTTTATTGACCATATTATTTATAGCCTTTAATGTGCTTATAACTTATAA
CGCAAATGTTGATAATCAATTATGGTTGATACCAGGATTATGTATTTGTGGCGTCGCTTTATTCACTAGTCTAATAATAG
CTATTATTTACACTGATTTGCTAAGCGAAATTATATTTTTCATAAATATTGTATTAGCACTTTACTATATTTATCCTATT
TTTTACGACTTCTTGTAA