Detailed information of TA system TA206060

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2441722..2442311
• Replicon: chromosome
• Accession: NZ_CP076628
• Organism: Xanthomonas arboricola pv. pruni strain IVIA 2626.1

Toxin (Protein)

• Gene name: graT
• Uniprot ID: A0A2S7AZR2
• Locus tag: KP026_RS10640
• Protein ID: WP_039429225.1
• Coordinates: 2442030..2442311 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KP026_RS10635
• Protein ID: WP_006449989.1
• Coordinates: 2441722..2442012 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KP026_RS10615 (KP026_10595)	2437864..2438700	+	837	WP_081327584.1	restriction endonuclease	-
KP026_RS10620 (KP026_10600)	2438775..2440673	+	1899	WP_126750750.1	hypothetical protein	-
KP026_RS10625 (KP026_10605)	2440847..2441179	+	333	WP_039513672.1	lipoprotein	-
KP026_RS10630	2441329..2441531	+	203	Protein_2037	hypothetical protein	-
KP026_RS10635 (KP026_10610)	2441722..2442012	-	291	WP_006449989.1	HigA family addiction module antitoxin	Antitoxin
KP026_RS10640 (KP026_10615)	2442030..2442311	-	282	WP_039429225.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KP026_RS10645 (KP026_10620)	2442451..2444577	-	2127	WP_043087609.1	exodeoxyribonuclease V subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-93)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (6-82)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11046.72 Da
• Isoelectric Point: 9.7972

>T206060 WP_039429225.1 NZ_CP076628:c2442311-2442030 [Xanthomonas arboricola pv. pruni]
MIRSFVDKEAEKIWLGERSRRLPADIQSVARRKLRMLNAAAHLDDLRIPPANRLEALKGERRGQYSIRINDQWRICFRWM
EGDVAEVEIVDYH

Nucleotide

• Length: 282 bp

>T206060 NZ_CP102089:849972-850178 [Staphylococcus capitis subsp. capitis]
ATGGAAAATGGAATTGTTTATGTTGCTAATATTGAGACTATAGAGGAAGAAAACCAATTAAAGACACGTTTAGAAAATAT
GATTGGTGTCGAAAAAGTAGATATTGATAGTAAAGTAGGAGAAATAAAGGTATTATTTGAAACGCCTGCGAATTTAAATA
GTATTGAAAAAGAAGTATATGATTCTGGCTTTCGCGTGCGTTATTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10540.20 Da
• Isoelectric Point: 6.4664

>AT206060 WP_006449989.1 NZ_CP076628:c2442012-2441722 [Xanthomonas arboricola pv. pruni]
MTVLPNIHPGEILLEEFLEPMGISQNALARATDVPPRRINEIVLGKRGITADTAVRLAAALGTTERFWLGLQADYELEQA
HRALGDLPSRIKRLAA

Nucleotide

• Length: 291 bp

>AT206060 NZ_CP102089:849664-849957 [Staphylococcus capitis subsp. capitis]
GTGACTGAAAATGAAACTGCACATCACTCAGAGCAAACGAAAGTAAATTTAAAGTCACGATTAAATCGTATCGAAGGTCA
AGTACGTGCAATTAATCGAATGATTGAAGACGATGTGTATTGCGATGATGTTTTAACTCAAATAAGAGCGACACGCTCTG
CTTTAAACAGTGTGGCTACTAAATTGTTAGATCATCATATGAAAAGTTGTATTATGAATAAAGTGAATAATGGTGCACAA
GAAGAAGCGATGGAAGAACTATTGGTTACTTTTCAAAAATTAATTAAAGATTAA

Structures

Toxin

• AlphaFold DB: A0A2S7AZR2