Detailed information of TA system TA206057

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 3333633..3334231
• Replicon: chromosome
• Accession: NZ_CP076623
• Organism: Morganella morganii strain CTX51T

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: KQH80_RS16065
• Protein ID: WP_052926456.1
• Coordinates: 3333953..3334231 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KQH80_RS16060
• Protein ID: WP_230059412.1
• Coordinates: 3333633..3333953 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQH80_RS16045 (KQH80_16035)	3328977..3332024	+	3048	WP_230059411.1	formate dehydrogenase-N subunit alpha	-
KQH80_RS16050 (KQH80_16040)	3332034..3332924	+	891	WP_046895109.1	formate dehydrogenase subunit beta	-
KQH80_RS16055 (KQH80_16045)	3332917..3333573	+	657	WP_004235987.1	formate dehydrogenase-N subunit gamma	-
KQH80_RS16060 (KQH80_16050)	3333633..3333953	-	321	WP_230059412.1	HigA family addiction module antitoxin	Antitoxin
KQH80_RS16065 (KQH80_16055)	3333953..3334231	-	279	WP_052926456.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KQH80_RS16070 (KQH80_16060)	3334363..3336867	-	2505	WP_218427535.1	bifunctional glycosyl transferase/transpeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (3-92)

Antitoxin

• Cro/C1-type helix-turn-helix domain (25-66)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10665.24 Da
• Isoelectric Point: 8.5628

>T206057 WP_052926456.1 NZ_CP076623:c3334231-3333953 [Morganella morganii]
MIKSFKHKGLKQLFENGVISGIPAQDAVRINDRLQAIDSATMIDDLNIHIYKLHPLRGDRVGIWSITVRANWRITFEFRN
GDAYILNLEDYH

Nucleotide

• Length: 279 bp

>T206057 NZ_CP102087:c1653668-1653462 [Staphylococcus capitis subsp. capitis]
ATGGAAAATGGAATTGTTTATGTTGCTAATATTGAGACTATAGAGGAAGAAAACCAATTAAAGACACGTTTAGAAAATAT
GATTGGTGTCGAAAAAGTAGATATTGATAGTAAAGTAGGAGAAATAAAGGTATTATTTGAAACGCCTGCGAATTTAAATA
GTATTGAAAAAGAAGTATATGATTCTGGCTTTCGCGTGCGTTATTAG

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11307.94 Da
• Isoelectric Point: 7.1642

>AT206057 WP_230059412.1 NZ_CP076623:c3333953-3333633 [Morganella morganii]
MKQAIVSHPGTIVANILTDLGVGVRQFAGNIGVTPATVSRFLSGKTALTPALAIRIAAALGSNPAFWLRLQANYDLHRLE
KEIDISGITLYGDSEEDGFCNRAPDK

Nucleotide

• Length: 321 bp

>AT206057 NZ_CP102087:c1653976-1653683 [Staphylococcus capitis subsp. capitis]
GTGACTGAAAATGAAACTGCACATCACTCAGAGCAAACGAAAGTAAATTTAAAGTCACGATTAAATCGTATCGAAGGTCA
AGTACGTGCAATTAATCGAATGATTGAAGACGATGTGTATTGCGATGATGTTTTAACTCAAATAAGAGCGACACGCTCTG
CTTTAAACAGTGTGGCTACTAAATTGTTAGATCATCATATGAAAAGTTGTATTATGAATAAAGTGAATAATGGTGCACAA
GAAGAAGCGATGGAAGAACTATTGGTTACTTTTCAAAAATTAATTAAAGATTAA