Detailed information of TA system TA206054

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 5079964..5080553
• Replicon: chromosome
• Accession: NZ_CP076619
• Organism: Xanthomonas arboricola pv. corylina strain CFBP 1846

Toxin (Protein)

• Gene name: graT
• Uniprot ID: A0A2N7V9W3
• Locus tag: KP021_RS21890
• Protein ID: WP_016902142.1
• Coordinates: 5080272..5080553 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: KP021_RS21885
• Protein ID: WP_026064232.1
• Coordinates: 5079964..5080254 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KP021_RS21860 (KP021_21795)	5076126..5077088	-	963	WP_070689987.1	IS1595 family transposase	-
KP021_RS21865 (KP021_21800)	5077238..5077606	+	369	WP_249452665.1	hypothetical protein	-
KP021_RS21870 (KP021_21805)	5078395..5078919	-	525	WP_039816184.1	hypothetical protein	-
KP021_RS21875 (KP021_21810)	5079089..5079421	+	333	WP_026064233.1	hypothetical protein	-
KP021_RS21880	5079571..5079773	+	203	Protein_4282	hypothetical protein	-
KP021_RS21885 (KP021_21815)	5079964..5080254	-	291	WP_026064232.1	HigA family addiction module antitoxin	Antitoxin
KP021_RS21890 (KP021_21820)	5080272..5080553	-	282	WP_016902142.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KP021_RS21895 (KP021_21825)	5080693..5082819	-	2127	WP_039816188.1	exodeoxyribonuclease V subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	5076126..5077088	962

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-67)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11064.75 Da
• Isoelectric Point: 9.7972

>T206054 WP_016902142.1 NZ_CP076619:c5080553-5080272 [Xanthomonas arboricola pv. corylina]
MIRSFVDKEAEKIWMGERSRRLPADIQSVARRKLRMLNAAAHLDDLRIPPANRLEALKGERRGQYSIRINDQWRICFRWM
EGDVAEVEIVDYH

Nucleotide

• Length: 282 bp

>T206054 NZ_CP102087:c622690-622229 [Staphylococcus capitis subsp. capitis]
ATGGGGTTATATGAAAAAATGTTAATAGAGCATGACTATATAGAAATCAGAGAAACAGATGTTATGCCTAATGACTTACA
CGGTTTATGGTTAGGCGATTTAATTCTAATTAAACGCAACCTTTCCGAAACACGCAAAGCCGAAGTGCTATACGAAGAAC
TAGCACATCACAAACTTACATATGGAAACATCTTAGATCAATCTAAAGATATAAACCGCAAATTTGAAAACTACGCTAGG
CGTTACGGATATGAAGCTGCTCTACCTTTACGCATTATTGTGGAGGCGCATAACTATGGTGTTAATAACTTATATGAACT
AGCTGAATATGTTCAATTAAGTGAAGAACACGTATTAGAAATATTGAATCATTACAAAAATAAATATGGTATTGGAACTC
ACTACGGAGAATACTTAATTACATTTGATCCGTTGAGGGTTTTTAAATATAAAGAAATATAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10555.21 Da
• Isoelectric Point: 8.7586

>AT206054 WP_026064232.1 NZ_CP076619:c5080254-5079964 [Xanthomonas arboricola pv. corylina]
MTVLPNIHPGEILREEFLEPMGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTTERFWLSLQADYELEQA
HRALGDLPSRIKRLAA

Nucleotide

• Length: 291 bp

>AT206054 NZ_CP102087:c623031-622702 [Staphylococcus capitis subsp. capitis]
ATGAGAAATAATGATGAAATAATCACAATAATTAAATCAGCTATGAAAGAACAAGATATGTCACTTAGTGAATTGGCTCG
TCGTGTTGGAGTTGCTAAATCTGCTGTATCACGTTATTTAAATTTAACTAGAGAATTCCCATTAAATCGTTCAGAAGATT
TTGCAAAAGCACTTAGTATCAGTACAGAATATTTACTTGGTTTTGATAAAAGTGAACAACAACATGAACAACCACAACAT
CGTGCAGCTCATCTTGAAGGCGAATTAACTGATGACGAATGGCAACGAGTTTTAGATTATGCTGATTTTATAAGAAGTAA
ACGTAAATAA

Structures

Toxin

• AlphaFold DB: A0A2N7V9W3