Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 1231060..1231318 Replicon chromosome
Accession NZ_CP076596
Organism Erwinia amylovora isolate CP20161301

Toxin (Protein)


Gene name hok Uniprot ID D4I1C1
Locus tag KQH32_RS05480 Protein ID WP_004160031.1
Coordinates 1231060..1231218 (-) Length 53 a.a.

Antitoxin (RNA)


Gene name sok
Locus tag -
Coordinates 1231272..1231318 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQH32_RS05465 (KQH32_05505) 1226365..1228056 - 1692 WP_004160025.1 chloride channel protein -
KQH32_RS05470 (KQH32_05510) 1228469..1229449 + 981 WP_013035818.1 TerC family protein -
KQH32_RS05475 (KQH32_05515) 1229684..1230916 + 1233 WP_004160030.1 serine/threonine transporter SstT -
KQH32_RS05480 (KQH32_05520) 1231060..1231218 - 159 WP_004160031.1 type I toxin-antitoxin system Hok family toxin Toxin
- 1231272..1231318 + 47 - - Antitoxin
KQH32_RS05485 (KQH32_05525) 1232029..1232703 + 675 WP_004160034.1 DedA family protein -
KQH32_RS05490 (KQH32_05530) 1232700..1233092 + 393 WP_004160035.1 EnvZ/OmpR regulon moderator MzrA -
KQH32_RS05495 (KQH32_05535) 1233260..1233631 + 372 WP_004160036.1 DUF1090 domain-containing protein -
KQH32_RS05500 (KQH32_05540) 1233674..1233979 + 306 WP_004160037.1 DUF883 family protein -
KQH32_RS05505 (KQH32_05545) 1233981..1234373 + 393 WP_004160038.1 phage holin family protein -
KQH32_RS05510 (KQH32_05550) 1234373..1234654 + 282 WP_004160039.1 YqjK-like family protein -
KQH32_RS05515 (KQH32_05555) 1234864..1235256 + 393 WP_004160048.1 DoxX family protein -
KQH32_RS05520 (KQH32_05560) 1235729..1235872 + 144 WP_004160049.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(8-48)


Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 6038.32 Da        Isoelectric Point: 8.4901

>T206023 WP_004160031.1 NZ_CP076596:c1231218-1231060 [Erwinia amylovora]
MKLPANCLIWCVLIVCVTLLIFTYLTRKSLCEIRYKDGYREVAAFMAYESGK

Download         Length: 159 bp

>T206023 NZ_CP102070:c2708780-2708637 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACGGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 47 bp

>AT206023 NZ_CP076596:1231272-1231318 [Erwinia amylovora]
GCATGCAGATGGCCTCGTGGATTAATGAAAATTAACTACGGGGCTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831A7I1

Antitoxin

Download structure file

References