20602

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2571166..2571683 Replicon chromosome
Accession NC_002952
Organism Staphylococcus aureus subsp. aureus MRSA252

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag SAR_RS13055 Protein ID WP_000251928.1
Coordinates 2571166..2571432 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag SAR_RS13060 Protein ID WP_000584497.1
Coordinates 2571432..2571683 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAR_RS13030 2566374..2566910 - 537 WP_000024292.1 GNAT family N-acetyltransferase -
SAR_RS13035 2567378..2568202 - 825 WP_000594640.1 formate/nitrite transporter family protein -
SAR_RS13040 2568405..2568587 - 183 WP_000079140.1 hypothetical protein -
SAR_RS13045 2568673..2569140 - 468 WP_000153340.1 SRPBCC domain-containing protein -
SAR_RS13050 2569326..2570873 - 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
SAR_RS13055 2571166..2571432 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
SAR_RS13060 2571432..2571683 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SAR_RS13065 2571847..2571947 - 101 Protein_2481 hypothetical protein -
SAR_RS13070 2571954..2572553 - 600 WP_000162804.1 DsbA family protein -
SAR_RS13075 2572572..2572934 - 363 WP_000819843.1 DUF4467 domain-containing protein -
SAR_RS13080 2573189..2574439 + 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
SAR_RS13085 2574532..2575263 - 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
SAR_RS13090 2575260..2575979 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-88)

Antitoxin

(1-74)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T20602 WP_000251928.1 NC_002952:c2571432-2571166 [Staphylococcus aureus subsp. aureus MRSA252]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T20602 NC_002952:c2571432-2571166 [Staphylococcus aureus subsp. aureus MRSA252]
ATGGTTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTAATTAAAAGTATTGACAGAAATGGTGCGTTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT20602 WP_000584497.1 NC_002952:c2571683-2571432 [Staphylococcus aureus subsp. aureus MRSA252]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT20602 NC_002952:c2571683-2571432 [Staphylococcus aureus subsp. aureus MRSA252]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATAGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTGTAACGAAAGAT
ATAGATGTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A170NWK0


Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References