Detailed information of TA system TA205993

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1243695..1243953
• Replicon: chromosome
• Accession: NZ_CP076592
• Organism: Erwinia amylovora isolate CP20140001

Toxin (Protein)

• Gene name: hok
• Uniprot ID: D4I1C1
• Locus tag: KQH33_RS05535
• Protein ID: WP_004160031.1
• Coordinates: 1243695..1243853 (-)
• Length: 53 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	1243907..1243953 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQH33_RS05520 (KQH33_05560)	1239000..1240691	-	1692	WP_004160025.1	chloride channel protein	-
KQH33_RS05525 (KQH33_05565)	1241104..1242084	+	981	WP_013035818.1	TerC family protein	-
KQH33_RS05530 (KQH33_05570)	1242319..1243551	+	1233	WP_004160030.1	serine/threonine transporter SstT	-
KQH33_RS05535 (KQH33_05575)	1243695..1243853	-	159	WP_004160031.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	1243907..1243953	+	47	-	-	Antitoxin
KQH33_RS05540 (KQH33_05580)	1244664..1245338	+	675	WP_004160034.1	DedA family protein	-
KQH33_RS05545 (KQH33_05585)	1245335..1245727	+	393	WP_004160035.1	EnvZ/OmpR regulon moderator MzrA	-
KQH33_RS05550 (KQH33_05590)	1245895..1246266	+	372	WP_004160036.1	DUF1090 domain-containing protein	-
KQH33_RS05555 (KQH33_05595)	1246309..1246614	+	306	WP_004160037.1	DUF883 family protein	-
KQH33_RS05560 (KQH33_05600)	1246616..1247008	+	393	WP_004160038.1	phage holin family protein	-
KQH33_RS05565 (KQH33_05605)	1247008..1247289	+	282	WP_004160039.1	YqjK-like family protein	-
KQH33_RS05570 (KQH33_05610)	1247499..1247891	+	393	WP_004160048.1	DoxX family protein	-
KQH33_RS05575 (KQH33_05615)	1248364..1248507	+	144	WP_004160049.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (8-48)

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 6038.32 Da
• Isoelectric Point: 8.4901

>T205993 WP_004160031.1 NZ_CP076592:c1243853-1243695 [Erwinia amylovora]
MKLPANCLIWCVLIVCVTLLIFTYLTRKSLCEIRYKDGYREVAAFMAYESGK

Nucleotide

• Length: 159 bp

>T205993 NZ_CP102061:c2113594-2113280 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Nucleotide

• Length: 47 bp

>AT205993 NZ_CP076592:1243907-1243953 [Erwinia amylovora]
GCATGCAGATGGCCTCGTGGATTAATGAAAATTAACTACGGGGCTTT

Structures

Toxin

• AlphaFold DB: A0A831A7I1

Antitoxin