Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2153418..2153841 Replicon chromosome
Accession NC_002952
Organism Staphylococcus aureus subsp. aureus MRSA252

Toxin (Protein)


Gene name higB Uniprot ID A0A7U7EW16
Locus tag SAR_RS10810 Protein ID WP_001065092.1
Coordinates 2153590..2153841 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag SAR_RS10805 Protein ID WP_000028422.1
Coordinates 2153418..2153600 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAR_RS10760 2148804..2150465 - 1662 WP_000625088.1 terminase large subunit -
SAR_RS10765 2150462..2150806 - 345 WP_000402904.1 hypothetical protein -
SAR_RS10770 2150936..2151235 - 300 WP_000988336.1 HNH endonuclease -
SAR_RS10775 2151467..2151883 - 417 WP_000590122.1 hypothetical protein -
SAR_RS10780 2151911..2152111 - 201 WP_000265043.1 DUF1514 family protein -
SAR_RS10785 2152111..2152260 - 150 WP_000595265.1 transcriptional activator RinB -
SAR_RS10790 2152257..2152643 - 387 WP_000592207.1 hypothetical protein -
SAR_RS10795 2152640..2152846 - 207 WP_000195803.1 DUF1381 domain-containing protein -
SAR_RS10800 2152883..2153425 - 543 WP_000185659.1 dUTP pyrophosphatase -
SAR_RS10805 2153418..2153600 - 183 WP_000028422.1 hypothetical protein Antitoxin
SAR_RS10810 2153590..2153841 - 252 WP_001065092.1 DUF1024 family protein Toxin
SAR_RS15785 2153834..2154001 - 168 WP_001624242.1 hypothetical protein -
SAR_RS10815 2154013..2154255 - 243 WP_000131366.1 hypothetical protein -
SAR_RS10820 2154259..2154627 - 369 WP_000101274.1 hypothetical protein -
SAR_RS10825 2154640..2154949 - 310 Protein_2056 RusA family crossover junction endodeoxyribonuclease -
SAR_RS10830 2154958..2155176 - 219 WP_000338531.1 hypothetical protein -
SAR_RS10835 2155183..2156056 - 874 Protein_2058 DnaD domain protein -
SAR_RS10840 2156086..2156556 - 471 WP_000934764.1 single-stranded DNA-binding protein -
SAR_RS10845 2156557..2157174 - 618 WP_071621397.1 MBL fold metallo-hydrolase -
SAR_RS10850 2157255..2158175 - 921 WP_000138472.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - map / hlb / scn / chp / sak / sea / hlb / groEL 2119976..2178968 58992


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9375.25 Da        Isoelectric Point: 3.8567

>T20598 WP_001065092.1 NC_002952:c2153841-2153590 [Staphylococcus aureus subsp. aureus MRSA252]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQYSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T20598 NC_002952:c2153841-2153590 [Staphylococcus aureus subsp. aureus MRSA252]
ATGAATAATCGCGAACAAATTGAACAATCAGTTATAAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTTTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAATATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT20598 WP_000028422.1 NC_002952:c2153600-2153418 [Staphylococcus aureus subsp. aureus MRSA252]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT20598 NC_002952:c2153600-2153418 [Staphylococcus aureus subsp. aureus MRSA252]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGAGCAGGAAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7EW16

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References