Detailed information of TA system TA205979

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2966397..2966655
• Replicon: chromosome
• Accession: NZ_CP076590
• Organism: Erwinia amylovora isolate CP200930

Toxin (Protein)

• Gene name: hok
• Uniprot ID: D4I1C1
• Locus tag: KQH39_RS13620
• Protein ID: WP_004160031.1
• Coordinates: 2966397..2966555 (-)
• Length: 53 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	2966609..2966655 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KQH39_RS13605 (KQH39_13645)	2961702..2963393	-	1692	WP_004160025.1	chloride channel protein	-
KQH39_RS13610 (KQH39_13650)	2963806..2964786	+	981	WP_013035818.1	TerC family protein	-
KQH39_RS13615 (KQH39_13655)	2965021..2966253	+	1233	WP_004160030.1	serine/threonine transporter SstT	-
KQH39_RS13620 (KQH39_13660)	2966397..2966555	-	159	WP_004160031.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	2966609..2966655	+	47	-	-	Antitoxin
KQH39_RS13625 (KQH39_13665)	2967366..2968040	+	675	WP_004160034.1	DedA family protein	-
KQH39_RS13630 (KQH39_13670)	2968037..2968429	+	393	WP_004160035.1	EnvZ/OmpR regulon moderator MzrA	-
KQH39_RS13635 (KQH39_13675)	2968597..2968968	+	372	WP_004160036.1	DUF1090 domain-containing protein	-
KQH39_RS13640 (KQH39_13680)	2969011..2969316	+	306	WP_004160037.1	DUF883 family protein	-
KQH39_RS13645 (KQH39_13685)	2969318..2969710	+	393	WP_004160038.1	phage holin family protein	-
KQH39_RS13650 (KQH39_13690)	2969710..2969991	+	282	WP_004160039.1	YqjK-like family protein	-
KQH39_RS13655 (KQH39_13695)	2970201..2970593	+	393	WP_004160048.1	DoxX family protein	-
KQH39_RS13660 (KQH39_13700)	2971066..2971209	+	144	WP_004160049.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (8-48)

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 6038.32 Da
• Isoelectric Point: 8.4901

>T205979 WP_004160031.1 NZ_CP076590:c2966555-2966397 [Erwinia amylovora]
MKLPANCLIWCVLIVCVTLLIFTYLTRKSLCEIRYKDGYREVAAFMAYESGK

Nucleotide

• Length: 159 bp

>T205979 NZ_CP101986:165647-165979 [Streptococcus mutans]
GTGGTAACCATCAAGCAAGGGTCAATTATCAAAATTAACTTGGATCCCAAACAAGGACATGAACAAAAAGGGTATCGTCC
GTACATTTGTCTAAACCATAGTATCGTAACCAAGTATTCTAATATTGCTATTTTTGCGCCAATTAGCAATACCAAGCGTG
ATTACCCTTTTTATGTTCCCCTAGAAGGAACAGAATCCACAGGGAAAGTATTATTAGACCAACTGGTTACAATCGATTTT
AATGCTAGAGATTATCGTTATGTGGAGGATATTCAGGAAGACTTATTAGATGAACTTTTAGCTAGGGTCAAGGTGCTATT
TGAAAAAGGATAA

Antitoxin

Nucleotide

• Length: 47 bp

>AT205979 NZ_CP076590:2966609-2966655 [Erwinia amylovora]
GCATGCAGATGGCCTCGTGGATTAATGAAAATTAACTACGGGGCTTT

Structures

Toxin

• AlphaFold DB: A0A831A7I1

Antitoxin