Detailed information of TA system TA020595

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2130100..2130407
• Replicon: chromosome
• Accession: NC_002952
• Organism: Staphylococcus aureus subsp. aureus MRSA252

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: SAR_RS15320
• Protein ID: WP_011447039.1
• Coordinates: 2130231..2130407 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2130100..2130239 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAR_RS10625	2125437..2125697	+	261	WP_001791826.1	hypothetical protein	-
SAR_RS10630	2125750..2126100	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
SAR_RS10635	2126786..2127235	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
SAR_RS15695	2127330..2127665	-	336	Protein_2017	SH3 domain-containing protein	-
SAR_RS10645	2128315..2128806	-	492	WP_000919350.1	staphylokinase	-
SAR_RS10650	2128998..2129753	-	756	WP_000861038.1	CHAP domain-containing protein	-
SAR_RS10655	2129765..2130019	-	255	WP_000611512.1	phage holin	-
SAR_RS10660	2130071..2130178	+	108	WP_001791821.1	hypothetical protein	-
-	2130100..2130239	+	140	NuclAT_0	-	Antitoxin
-	2130100..2130239	+	140	NuclAT_0	-	Antitoxin
-	2130100..2130239	+	140	NuclAT_0	-	Antitoxin
-	2130100..2130239	+	140	NuclAT_0	-	Antitoxin
SAR_RS15320	2130231..2130407	-	177	WP_011447039.1	putative holin-like toxin	Toxin
SAR_RS10670	2130516..2131289	-	774	WP_000750406.1	staphylococcal enterotoxin type A	-
SAR_RS10675	2131710..2132084	-	375	WP_000340977.1	hypothetical protein	-
SAR_RS10680	2132140..2132427	-	288	WP_001040259.1	hypothetical protein	-
SAR_RS10685	2132474..2132626	-	153	WP_001153681.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / chp / sak / sea / hlb / groEL	2119976..2178968	58992

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T20595 WP_011447039.1 NC_002952:c2130407-2130231 [Staphylococcus aureus subsp. aureus MRSA252]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T20595 NC_002952:c2130407-2130231 [Staphylococcus aureus subsp. aureus MRSA252]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT20595 NC_002952:2130100-2130239 [Staphylococcus aureus subsp. aureus MRSA252]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin