Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3746797..3747490 Replicon chromosome
Accession NZ_CP076527
Organism Escherichia coli strain L3452210II

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag KPE21_RS18145 Protein ID WP_000415585.1
Coordinates 3746797..3747093 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KPE21_RS18150 Protein ID WP_000650107.1
Coordinates 3747095..3747490 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPE21_RS24310 (3741931) 3741931..3742410 + 480 WP_000065332.1 Hcp family type VI secretion system effector -
KPE21_RS24315 (3742413) 3742413..3743123 + 711 WP_000834030.1 hypothetical protein -
KPE21_RS18120 (3743130) 3743130..3743462 + 333 WP_000914690.1 DUF2645 family protein -
KPE21_RS18125 (3743508) 3743508..3744857 - 1350 WP_000673358.1 quorum sensing histidine kinase QseC -
KPE21_RS18130 (3744854) 3744854..3745513 - 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
KPE21_RS18135 (3745665) 3745665..3746057 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
KPE21_RS18140 (3746110) 3746110..3746592 + 483 WP_000183505.1 GyrI-like domain-containing protein -
KPE21_RS18145 (3746797) 3746797..3747093 + 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
KPE21_RS18150 (3747095) 3747095..3747490 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KPE21_RS18155 (3747623) 3747623..3749230 + 1608 WP_001375094.1 ABC transporter substrate-binding protein -
KPE21_RS18160 (3749368) 3749368..3751626 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T205928 WP_000415585.1 NZ_CP076527:3746797-3747093 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T205928 NZ_CP101925:4269463-4269615 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT205928 WP_000650107.1 NZ_CP076527:3747095-3747490 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT205928 NZ_CP101925:c4269414-4269357 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References