Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2217054..2217312 Replicon chromosome
Accession NZ_CP076527
Organism Escherichia coli strain L3452210II

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag KPE21_RS10800 Protein ID WP_000809168.1
Coordinates 2217160..2217312 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 2217054..2217111 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPE21_RS24255 2212102..2213433 + 1332 Protein_2117 fimbria/pilus outer membrane usher protein -
KPE21_RS10785 2213446..2214404 + 959 Protein_2118 fimbrial family protein -
KPE21_RS10790 2214443..2215342 - 900 WP_001300855.1 transcriptional activator NhaR -
KPE21_RS10795 2215408..2216574 - 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
- 2217054..2217111 - 58 - - Antitoxin
KPE21_RS10800 2217160..2217312 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
KPE21_RS10805 2217416..2218546 - 1131 WP_001118464.1 molecular chaperone DnaJ -
KPE21_RS10810 2218635..2220551 - 1917 WP_000516131.1 molecular chaperone DnaK -
KPE21_RS10815 2220928..2221332 + 405 WP_000843559.1 DUF2541 family protein -
KPE21_RS10820 2221358..2222071 + 714 WP_001102383.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T205922 WP_000809168.1 NZ_CP076527:2217160-2217312 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T205922 NZ_CP101925:2833342-2833449 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCGTGATTTTCTGGCACGACCTGGCAGCACCGATCCTTGCGGGAATTATTACCGCAGCGAT
TGTTGGCTGGTGGCGTAGCCGGAAGTAA

Antitoxin


Download         Length: 58 bp

>AT205922 NZ_CP076527:c2217111-2217054 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References