Detailed information of TA system TA020592

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1972690..1972870
• Replicon: chromosome
• Accession: NC_002952
• Organism: Staphylococcus aureus subsp. aureus MRSA252

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: SAR_RS15670
• Protein ID: WP_001801861.1
• Coordinates: 1972690..1972785 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1972813..1972870 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAR_RS09645	1967834..1968460	+	627	WP_000669038.1	hypothetical protein	-
SAR_RS09650	1968501..1968845	+	345	WP_000627550.1	DUF3969 family protein	-
SAR_RS09655	1968943..1969515	+	573	WP_000414222.1	hypothetical protein	-
SAR_RS09660	1969664..1971031	-	1368	WP_001093574.1	FRG domain-containing protein	-
SAR_RS09665	1971031..1971600	-	570	WP_000125075.1	ImmA/IrrE family metallo-endopeptidase	-
SAR_RS09670	1971793..1972239	-	447	WP_000747804.1	DUF1433 domain-containing protein	-
SAR_RS15670	1972690..1972785	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1972813..1972870	-	58	-	-	Antitoxin
SAR_RS09675	1972908..1973009	+	102	WP_001791232.1	hypothetical protein	-
SAR_RS09680	1973184..1973627	-	444	WP_001037039.1	DUF1433 domain-containing protein	-
SAR_RS09685	1973627..1974070	-	444	WP_000731421.1	DUF1433 domain-containing protein	-
SAR_RS15250	1974070..1974512	-	443	Protein_1870	DUF1433 domain-containing protein	-
SAR_RS09695	1975037..1977457	+	2421	WP_000182553.1	polysaccharide lyase 8 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T20592 WP_001801861.1 NC_002952:1972690-1972785 [Staphylococcus aureus subsp. aureus MRSA252]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T20592 NC_002952:1972690-1972785 [Staphylococcus aureus subsp. aureus MRSA252]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT20592 NC_002952:c1972870-1972813 [Staphylococcus aureus subsp. aureus MRSA252]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin