Detailed information of TA system TA020589

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1630996..1631575
• Replicon: chromosome
• Accession: NC_002952
• Organism: Staphylococcus aureus subsp. aureus MRSA252

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: SAR_RS07955
• Protein ID: WP_001025401.1
• Coordinates: 1631330..1631575 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1630996..1631361 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAR_RS07915	1627737..1628294	-	558	WP_000645048.1	DUF2815 family protein	-
SAR_RS07920	1628320..1629486	-	1167	WP_000762529.1	DUF2800 domain-containing protein	-
SAR_RS07925	1629483..1629845	-	363	WP_000985973.1	hypothetical protein	-
SAR_RS07930	1629860..1630183	-	324	WP_000174999.1	hypothetical protein	-
SAR_RS07935	1630262..1630423	-	162	WP_001285948.1	DUF1270 domain-containing protein	-
SAR_RS07940	1630436..1630699	-	264	WP_001124193.1	helix-turn-helix domain-containing protein	-
SAR_RS07945	1630726..1630941	-	216	WP_001097552.1	hypothetical protein	-
SAR_RS07950	1630996..1631361	+	366	WP_001128433.1	hypothetical protein	Antitoxin
SAR_RS07955	1631330..1631575	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
SAR_RS07960	1631642..1632022	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
SAR_RS07965	1632009..1632206	-	198	WP_001148860.1	hypothetical protein	-
SAR_RS07970	1632276..1632488	+	213	WP_000362644.1	hypothetical protein	-
SAR_RS15770	1632529..1632678	-	150	WP_000771849.1	hypothetical protein	-
SAR_RS07975	1632693..1633136	-	444	WP_000435362.1	hypothetical protein	-
SAR_RS07980	1633154..1633378	-	225	WP_000333485.1	DUF739 family protein	-
SAR_RS07985	1633540..1633920	+	381	WP_001089477.1	helix-turn-helix domain-containing protein	-
SAR_RS07990	1633942..1634400	+	459	WP_000521395.1	hypothetical protein	-
SAR_RS07995	1634418..1634852	+	435	WP_000755719.1	hypothetical protein	-
SAR_RS08000	1634881..1635276	+	396	WP_000449656.1	hypothetical protein	-
SAR_RS08005	1635475..1636098	-	624	WP_001166482.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1591421..1650186	58765

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T20589 WP_001025401.1 NC_002952:c1631575-1631330 [Staphylococcus aureus subsp. aureus MRSA252]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T20589 NC_002952:c1631575-1631330 [Staphylococcus aureus subsp. aureus MRSA252]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT20589 NC_002952:1630996-1631361 [Staphylococcus aureus subsp. aureus MRSA252]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin