Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | fst-RNAII/Fst(toxin) |
| Location | 41164..41405 | Replicon | plasmid pUAMSEL2 |
| Accession | NZ_CP076500 | ||
| Organism | Enterococcus faecalis strain UAMS_EL53 | ||
Toxin (Protein)
| Gene name | fst | Uniprot ID | - |
| Locus tag | KPU58_RS15890 | Protein ID | WP_002360667.1 |
| Coordinates | 41164..41274 (+) | Length | 37 a.a. |
Antitoxin (RNA)
| Gene name | RNAII | ||
| Locus tag | - | ||
| Coordinates | 41314..41405 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KPU58_RS15845 (36240) | 36240..36497 | + | 258 | WP_010824092.1 | hypothetical protein | - |
| KPU58_RS15850 (36494) | 36494..36832 | + | 339 | WP_049098551.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| KPU58_RS15855 (37037) | 37037..37654 | + | 618 | WP_025191668.1 | recombinase family protein | - |
| KPU58_RS15860 (37695) | 37695..37994 | + | 300 | WP_142657760.1 | BRCT domain-containing protein | - |
| KPU58_RS15865 (38028) | 38028..38225 | + | 198 | WP_048669782.1 | hypothetical protein | - |
| KPU58_RS15870 (38493) | 38493..38810 | + | 318 | WP_224813313.1 | DUF6440 family protein | - |
| KPU58_RS15875 (39238) | 39238..40566 | + | 1329 | WP_002400994.1 | ultraviolet resistance protein UvrA | - |
| KPU58_RS15880 (40563) | 40563..40913 | + | 351 | WP_002400993.1 | hypothetical protein | - |
| KPU58_RS15885 (40870) | 40870..41082 | + | 213 | WP_002360669.1 | hypothetical protein | - |
| KPU58_RS15890 (41164) | 41164..41274 | + | 111 | WP_002360667.1 | type I toxin-antitoxin system Fst family toxin | Toxin |
| - (41314) | 41314..41405 | - | 92 | NuclAT_0 | - | Antitoxin |
| - (41314) | 41314..41405 | - | 92 | NuclAT_0 | - | Antitoxin |
| - (41314) | 41314..41405 | - | 92 | NuclAT_0 | - | Antitoxin |
| - (41314) | 41314..41405 | - | 92 | NuclAT_0 | - | Antitoxin |
| KPU58_RS15895 (41546) | 41546..41809 | + | 264 | WP_082148692.1 | type III secretion system protein PrgN | - |
| KPU58_RS15900 (41976) | 41976..42317 | - | 342 | WP_002382053.1 | hypothetical protein | - |
| KPU58_RS15905 (42321) | 42321..43223 | - | 903 | WP_002382055.1 | AAA family ATPase | - |
| KPU58_RS15910 (43619) | 43619..44620 | + | 1002 | WP_142657759.1 | replication initiator protein A | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | EF0149 | 1..55301 | 55301 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 37 a.a. Molecular weight: 4117.92 Da Isoelectric Point: 4.1672
>T205881 WP_002360667.1 NZ_CP076500:41164-41274 [Enterococcus faecalis]
VLFVKDLMSLVIAPIFVGLVLEMISRVLDEEDDNRK
VLFVKDLMSLVIAPIFVGLVLEMISRVLDEEDDNRK
Download Length: 111 bp
>T205881 NZ_CP101921:c2462376-2462200 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
Antitoxin
Download Length: 92 bp
>AT205881 NZ_CP076500:c41405-41314 [Enterococcus faecalis]
TAAAAATATGTTATACTAAAGGTGCGAAACGACATTAAATCGTACAAATAACACAAAAAGCAATCCTACGGCGAATAGGA
TTGCTTTTTTTT
TAAAAATATGTTATACTAAAGGTGCGAAACGACATTAAATCGTACAAATAACACAAAAAGCAATCCTACGGCGAATAGGA
TTGCTTTTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
