Detailed information of TA system TA020588

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1046788..1047037
• Replicon: chromosome
• Accession: NC_002952
• Organism: Staphylococcus aureus subsp. aureus MRSA252

Toxin (Protein)

• Gene name: SprG2
• Uniprot ID: -
• Locus tag: SAR_RS05085
• Protein ID: WP_000623369.1
• Coordinates: 1046788..1046895 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	1046890..1047037 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAR_RS05060	1043461..1044030	-	570	WP_000287265.1	competence protein ComK	-
SAR_RS05065	1044240..1044458	+	219	WP_000876825.1	IDEAL domain-containing protein	-
SAR_RS05070	1044539..1045525	-	987	WP_000668820.1	lipoate--protein ligase	-
SAR_RS05075	1045724..1045900	+	177	WP_000214898.1	YkvS family protein	-
SAR_RS05080	1045915..1046517	+	603	WP_001033867.1	CPBP family intramembrane metalloprotease	-
SAR_RS05085	1046788..1046895	+	108	WP_000623369.1	putative holin-like toxin	Toxin
-	1046890..1047037	-	148	-	-	Antitoxin
SAR_RS05090	1047434..1047535	+	102	WP_001790623.1	hypothetical protein	-
SAR_RS15040	1047545..1047817	+	273	WP_001794574.1	lactococcin 972 family bacteriocin	-
SAR_RS05095	1047861..1049825	+	1965	WP_000870819.1	bacteriocin-associated integral membrane family protein	-
SAR_RS05100	1049828..1050148	+	321	WP_000873929.1	YxeA family protein	-
SAR_RS05105	1050145..1050786	+	642	WP_000571191.1	ABC transporter ATP-binding protein	-
SAR_RS15045	1050874..1051164	-	291	WP_001791476.1	hypothetical protein	-
SAR_RS05115	1051505..1051792	+	288	WP_000410718.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (3-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3801.69 Da
• Isoelectric Point: 10.8004

>T20588 WP_000623369.1 NC_002952:1046788-1046895 [Staphylococcus aureus subsp. aureus MRSA252]
VISIANALHLMLSFGMFIVTFIGVVVAIINLNNKK

Nucleotide

• Length: 108 bp

>T20588 NC_002952:1046788-1046895 [Staphylococcus aureus subsp. aureus MRSA252]
GTGATATCTATTGCAAACGCATTACATTTAATGTTAAGTTTCGGTATGTTTATCGTCACTTTCATTGGTGTAGTAGTCGC
AATAATTAATTTAAACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 148 bp

>AT20588 NC_002952:c1047037-1046890 [Staphylococcus aureus subsp. aureus MRSA252]
CAATTAAATAAAAGATATGTTACTATAAAAATGTAAAAAGACGACATGCAGGAACATGTCGCCTAATGAGCCCGTTAAAA
AGACGGTGACTAAATGAGATTTTCTTTAACCATCATTCGTTGTCAAAGTTTTGAAATGATGGTTATTT

Structures

Antitoxin