Detailed information of TA system TA205873

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): fst-ratA/Fst(toxin)
• Location: 2504..2745
• Replicon: plasmid pUAMSEL1
• Accession: NZ_CP076499
• Organism: Enterococcus faecalis strain UAMS_EL53

Toxin (Protein)

• Gene name: fst
• Uniprot ID: -
• Locus tag: KPU58_RS14935
• Protein ID: WP_002360667.1
• Coordinates: 2504..2614 (+)
• Length: 37 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2654..2745 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KPU58_RS14920 (578)	578..1906	+	1329	WP_129268066.1	ultraviolet resistance protein UvrA	-
KPU58_RS14925 (1903)	1903..2253	+	351	WP_002360672.1	hypothetical protein	-
KPU58_RS14930 (2210)	2210..2422	+	213	Protein_3	excinuclease ABC subunit C	-
KPU58_RS14935 (2504)	2504..2614	+	111	WP_002360667.1	type I toxin-antitoxin system Fst family toxin	Toxin
- (2654)	2654..2745	-	92	NuclAT_0	-	Antitoxin
- (2654)	2654..2745	-	92	NuclAT_0	-	Antitoxin
- (2654)	2654..2745	-	92	NuclAT_0	-	Antitoxin
- (2654)	2654..2745	-	92	NuclAT_0	-	Antitoxin
KPU58_RS14940 (2854)	2854..3144	+	291	WP_001137528.1	hypothetical protein	-
KPU58_RS14945 (3248)	3248..3619	-	372	WP_000049959.1	replication-associated protein RepC	-
KPU58_RS14950 (3612)	3612..4457	-	846	WP_000239313.1	AAA family ATPase	-
KPU58_RS14955 (4929)	4929..5939	+	1011	WP_001058676.1	replication initiator protein A	-
KPU58_RS14960 (5983)	5983..6966	+	984	WP_000007382.1	prolipoprotein diacylglyceryl transferase	-
KPU58_RS14965 (6891)	6891..7079	+	189	Protein_10	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	erm(B) / ant(6)-Ia / aph(3')-III	cylR2 / cylR1 / cylL / cylS / cylM / cylB / cylA / cylI	1..119720	119720

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 37 a.a.
• Molecular weight: 4117.92 Da
• Isoelectric Point: 4.1672

>T205873 WP_002360667.1 NZ_CP076499:2504-2614 [Enterococcus faecalis]
VLFVKDLMSLVIAPIFVGLVLEMISRVLDEEDDNRK

Nucleotide

• Length: 111 bp

>T205873 NZ_CP101921:861926-862333 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Nucleotide

• Length: 92 bp

>AT205873 NZ_CP076499:c2745-2654 [Enterococcus faecalis]
TAAAAATATGTTATACTAAAGGTGCGAAACGACATTAAATCGTACAAATAACACAAAAAGCAATCCTACGGCGAATAGGA
TTGCTTTTTTTT

Structures

Antitoxin