205868

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2924282..2924514 Replicon chromosome
Accession NZ_CP076498
Organism Enterococcus faecalis strain UAMS_EL53

Toxin (Protein)


Gene name txpA Uniprot ID Q837V5
Locus tag KPU58_RS14415 Protein ID WP_002366178.1
Coordinates 2924398..2924514 (-) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2924282..2924487 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPU58_RS14395 2919769..2920857 - 1089 WP_002355572.1 diacylglycerol kinase -
KPU58_RS14400 2920876..2922306 - 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
KPU58_RS14405 2922306..2923775 - 1470 WP_002361259.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
KPU58_RS14410 2923775..2924080 - 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
- 2924282..2924487 + 206 - - Antitoxin
KPU58_RS14415 2924398..2924514 - 117 WP_002366178.1 putative holin-like toxin Toxin
KPU58_RS14420 2924662..2926692 - 2031 WP_002361258.1 NAD-dependent DNA ligase LigA -
KPU58_RS14425 2926818..2929076 - 2259 WP_002363179.1 DNA helicase PcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4108.01 Da        Isoelectric Point: 5.9482

>T205868 WP_002366178.1 NZ_CP076498:c2924514-2924398 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFVILALVLDNKNNRS

Download         Length: 117 bp

>T205868 NZ_CP101921:198755-198862 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 206 bp

>AT205868 NZ_CP076498:2924282-2924487 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAGTAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAA
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1G1S9M0

Antitoxin

Download structure file

References