Detailed information of TA system TA205864

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 741807..742064
• Replicon: chromosome
• Accession: NZ_CP076498
• Organism: Enterococcus faecalis strain UAMS_EL53

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: KPU58_RS03785
• Protein ID: WP_021164441.1
• Coordinates: 741807..741908 (+)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	741857..742064 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KPU58_RS03770	738241..738741	-	501	WP_002378961.1	cysteine hydrolase family protein	-
KPU58_RS03775	738912..741182	+	2271	WP_002399785.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
KPU58_RS03780	741373..741474	+	102	WP_021164442.1	putative holin-like toxin	-
KPU58_RS03785	741807..741908	+	102	WP_021164441.1	putative holin-like toxin	Toxin
-	741857..742064	-	208	-	-	Antitoxin
KPU58_RS03790	742090..742542	-	453	WP_002378959.1	YueI family protein	-
KPU58_RS03795	742727..743674	+	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
KPU58_RS03800	743671..744636	+	966	WP_002387376.1	iron chelate uptake ABC transporter family permease subunit	-
KPU58_RS03805	744633..745388	+	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
KPU58_RS03810	745427..746380	+	954	WP_002370087.1	siderophore ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3598.36 Da
• Isoelectric Point: 6.0656

>T205864 WP_021164441.1 NZ_CP076498:741807-741908 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNNKK

Nucleotide

• Length: 102 bp

>T205864 NZ_CP101920:3708466-3708684 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Nucleotide

• Length: 208 bp

>AT205864 NZ_CP076498:c742064-741857 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAAC
ACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTAT
TTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin