Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2523369..2523892 Replicon chromosome
Accession NC_002951
Organism Staphylococcus aureus subsp. aureus COL

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag SACOL_RS12925 Protein ID WP_000074048.1
Coordinates 2523369..2523635 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag SACOL_RS12930 Protein ID WP_000587616.1
Coordinates 2523635..2523892 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SACOL_RS12905 2518676..2519863 - 1188 WP_000026194.1 MFS transporter -
SACOL_RS12910 2520259..2521035 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
SACOL_RS12915 2521028..2521690 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
SACOL_RS12920 2521938..2523014 - 1077 WP_001076671.1 M42 family metallopeptidase -
SACOL_RS12925 2523369..2523635 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
SACOL_RS12930 2523635..2523892 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SACOL_RS12940 2524251..2524706 + 456 WP_000732082.1 DUF1307 domain-containing protein -
SACOL_RS12945 2524874..2526451 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
SACOL_RS12950 2526646..2527395 + 750 WP_000072443.1 hypothetical protein -
SACOL_RS12955 2527619..2528812 - 1194 WP_000675395.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T20586 WP_000074048.1 NC_002951:c2523635-2523369 [Staphylococcus aureus subsp. aureus COL]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T20586 NC_002951:c2523635-2523369 [Staphylococcus aureus subsp. aureus COL]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT20586 WP_000587616.1 NC_002951:c2523892-2523635 [Staphylococcus aureus subsp. aureus COL]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT20586 NC_002951:c2523892-2523635 [Staphylococcus aureus subsp. aureus COL]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References