Detailed information of TA system TA205850

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 564855..565253
• Replicon: chromosome
• Accession: NZ_CP076498
• Organism: Enterococcus faecalis strain UAMS_EL53

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q82Z30
• Locus tag: KPU58_RS02965
• Protein ID: WP_002387585.1
• Coordinates: 564855..564998 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	565109..565253 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KPU58_RS02960	561606..564665	+	3060	WP_002387586.1	WxL domain-containing protein	-
KPU58_RS02965	564855..564998	-	144	WP_002387585.1	putative holin-like toxin	Toxin
-	565109..565253	+	145	-	-	Antitoxin
KPU58_RS02970	565594..569352	+	3759	WP_010706868.1	WxL domain-containing protein	-
KPU58_RS02975	569542..569685	-	144	WP_277813408.1	type I toxin-antitoxin system toxin PepG1	-
KPU58_RS16495	569918..569992	-	75	Protein_555	type I toxin-antitoxin system toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5244.37 Da
• Isoelectric Point: 10.5719

>T205850 WP_002387585.1 NZ_CP076498:c564998-564855 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILKVVKEDKKK

Nucleotide

• Length: 144 bp

>T205850 NZ_CP101920:c607485-607021 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Nucleotide

• Length: 145 bp

>AT205850 NZ_CP076498:565109-565253 [Enterococcus faecalis]
TTGTGCTATAATAGCAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCTTT
TTAGTTACAAAAAATAACCGTACTCAGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGC

Structures

Toxin

• AlphaFold DB: A0A059MXV6

Antitoxin