Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2491868..2492052 Replicon chromosome
Accession NC_002951
Organism Staphylococcus aureus subsp. aureus COL

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag SACOL_RS12770 Protein ID WP_000482650.1
Coordinates 2491945..2492052 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2491868..2491928 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SACOL_RS12745 2487398..2487565 - 168 WP_001790576.1 hypothetical protein -
SACOL_RS12755 2487796..2489529 - 1734 WP_000486498.1 ABC transporter ATP-binding protein/permease -
SACOL_RS12760 2489554..2491317 - 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
- 2491868..2491928 + 61 - - Antitoxin
SACOL_RS12770 2491945..2492052 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
SACOL_RS12775 2492187..2492573 - 387 WP_000779358.1 flippase GtxA -
SACOL_RS12780 2492841..2493983 + 1143 WP_001176863.1 glycerate kinase -
SACOL_RS12785 2494043..2494702 + 660 WP_000831298.1 membrane protein -
SACOL_RS12790 2494884..2496095 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
SACOL_RS12795 2496218..2496691 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T20584 WP_000482650.1 NC_002951:c2492052-2491945 [Staphylococcus aureus subsp. aureus COL]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T20584 NC_002951:c2492052-2491945 [Staphylococcus aureus subsp. aureus COL]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT20584 NC_002951:2491868-2491928 [Staphylococcus aureus subsp. aureus COL]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References