Detailed information of TA system TA205830

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): fst-ratA/Fst(toxin)
• Location: 388..629
• Replicon: plasmid pUAMSEL1
• Accession: NZ_CP076494
• Organism: Enterococcus faecalis strain UAMS_EL54

Toxin (Protein)

• Gene name: fst
• Uniprot ID: -
• Locus tag: KPU55_RS14935
• Protein ID: WP_002360667.1
• Coordinates: 519..629 (-)
• Length: 37 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	388..479 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
- (388)	388..479	+	92	NuclAT_0	-	Antitoxin
- (388)	388..479	+	92	NuclAT_0	-	Antitoxin
- (388)	388..479	+	92	NuclAT_0	-	Antitoxin
- (388)	388..479	+	92	NuclAT_0	-	Antitoxin
KPU55_RS14935 (519)	519..629	-	111	WP_002360667.1	type I toxin-antitoxin system Fst family toxin	Toxin
KPU55_RS14940 (711)	711..923	-	213	Protein_2	excinuclease ABC subunit C	-
KPU55_RS14945 (880)	880..1230	-	351	WP_002360672.1	hypothetical protein	-
KPU55_RS14950 (1227)	1227..2555	-	1329	WP_129268066.1	ultraviolet resistance protein UvrA	-
KPU55_RS14955 (2984)	2984..3286	-	303	WP_002372577.1	DUF6440 family protein	-
KPU55_RS14960 (3298)	3298..3507	-	210	WP_002382045.1	hypothetical protein	-
KPU55_RS14965 (3568)	3568..3792	-	225	WP_002383635.1	ultraviolet resistance protein UvrA repressor UvrC	-
KPU55_RS14970 (3786)	3786..4100	-	315	WP_002383634.1	hypothetical protein	-
KPU55_RS14975 (4090)	4090..4197	-	108	Protein_9	recombinase family protein	-
KPU55_RS14980 (4271)	4271..5432	+	1162	Protein_10	IS3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	aph(3')-III / ant(6)-Ia / erm(B)	cylI / cylA / cylB / cylM / cylS / cylL / cylR1 / cylR2	1..119714	119714
	-	flank	IS/Tn	-	-	4596..5432	836

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 37 a.a.
• Molecular weight: 4117.92 Da
• Isoelectric Point: 4.1672

>T205830 WP_002360667.1 NZ_CP076494:c629-519 [Enterococcus faecalis]
VLFVKDLMSLVIAPIFVGLVLEMISRVLDEEDDNRK

Nucleotide

• Length: 111 bp

>T205830 NZ_CP101915:c1785849-1785472 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin

Nucleotide

• Length: 92 bp

>AT205830 NZ_CP076494:388-479 [Enterococcus faecalis]
TAAAAATATGTTATACTAAAGGTGCGAAACGACATTAAATCGTACAAATAACACAAAAAGCAATCCTACGGCGAATAGGA
TTGCTTTTTTTT

Structures

Antitoxin