Detailed information of TA system TA205826

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2990022..2990420
• Replicon: chromosome
• Accession: NZ_CP076493
• Organism: Enterococcus faecalis strain UAMS_EL54

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: KPU55_RS14725
• Protein ID: WP_277813408.1
• Coordinates: 2990022..2990165 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2990266..2990420 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KPU55_RS14715	2985335..2985478	-	144	WP_002387585.1	putative holin-like toxin	-
KPU55_RS14720	2986074..2989832	+	3759	WP_010706868.1	WxL domain-containing protein	-
KPU55_RS14725	2990022..2990165	-	144	WP_277813408.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	2990266..2990420	+	155	-	-	Antitoxin
KPU55_RS16500	2990398..2990472	-	75	Protein_2875	type I toxin-antitoxin system toxin	-
KPU55_RS14730	2990728..2992344	-	1617	WP_002379014.1	phosphatase PAP2/LCP family protein	-
KPU55_RS14735	2992806..2994101	+	1296	WP_002379013.1	ATP-binding protein	-
KPU55_RS14740	2994110..2994742	+	633	WP_002358972.1	RloB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5395.58 Da
• Isoelectric Point: 10.8331

>T205826 WP_277813408.1 NZ_CP076493:c2990165-2990022 [Enterococcus faecalis]
MHVFPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 144 bp

>T205826 NZ_CP101915:850628-851035 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Nucleotide

• Length: 155 bp

>AT205826 NZ_CP076493:2990266-2990420 [Enterococcus faecalis]
TTTTTAGGTAAGTGTGCTATAATAGCAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCGGTTTAAGA
CGGTGACCTTTTGGATTATTTAAAAATAACCGTACTTGGTCAAAGTAGACGGTTATTTTTTCTTGTCTTCTTTAA

Structures

Antitoxin