Detailed information of TA system TA205822

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2985335..2985733
• Replicon: chromosome
• Accession: NZ_CP076493
• Organism: Enterococcus faecalis strain UAMS_EL54

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q82Z30
• Locus tag: KPU55_RS14715
• Protein ID: WP_002387585.1
• Coordinates: 2985335..2985478 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2985589..2985733 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KPU55_RS14710	2982086..2985145	+	3060	WP_002387586.1	WxL domain-containing protein	-
KPU55_RS14715	2985335..2985478	-	144	WP_002387585.1	putative holin-like toxin	Toxin
-	2985589..2985733	+	145	-	-	Antitoxin
KPU55_RS14720	2986074..2989832	+	3759	WP_010706868.1	WxL domain-containing protein	-
KPU55_RS14725	2990022..2990165	-	144	WP_277813408.1	type I toxin-antitoxin system toxin PepG1	-
KPU55_RS16500	2990398..2990472	-	75	Protein_2875	type I toxin-antitoxin system toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5244.37 Da
• Isoelectric Point: 10.5719

>T205822 WP_002387585.1 NZ_CP076493:c2985478-2985335 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILKVVKEDKKK

Nucleotide

• Length: 144 bp

>T205822 NZ_CP101914:1118862-1119224 [Oceanobacillus jeddahense]
GTGATCGTTCAAAGAGGCGAGGTTTATTTTGCTGACTTATCCCCTGTGGTTGGTTCAGAGCAGGGTGGTGTGCGACCAGT
TCTTATTATTCAAAATGATATAGGGAATCGGTTTAGCCCGACTGTGATTGTAGCAGCTATTACAGCGCAAATACAAAAGG
CTAAATTACCTACGCATGTGGAGATTGATGCAAAGCGTTATGGATTTGATCGGAATTCAGTCATTTTATTAGAACAAATT
CGTACATTAGATAAGCAGCGATTAACGGATAAAATTACAAAATTAGATAAAGAAATGATGGAAAAAATCGATCAATCATT
AGAAATAAGCCTCGGCTTACGAGATGTGTACAGTAATAATTAA

Antitoxin

Nucleotide

• Length: 145 bp

>AT205822 NZ_CP076493:2985589-2985733 [Enterococcus faecalis]
TTGTGCTATAATAGCAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCTTT
TTAGTTACAAAAAATAACCGTACTCAGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGC

Structures

Toxin

• AlphaFold DB: A0A059MXV6

Antitoxin