Detailed information of TA system TA205790

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 60955..61291
• Replicon: plasmid pUAMSEL1
• Accession: NZ_CP076489
• Organism: Enterococcus faecalis strain UAMS_EL56

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: KPU60_RS16490
• Protein ID: WP_141435800.1
• Coordinates: 60955..61101 (+)
• Length: 49 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	61035..61291 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KPU60_RS15265	56163..57476	-	1314	WP_002398555.1	hypothetical protein	-
KPU60_RS16465	57466..57597	-	132	WP_000159353.1	hypothetical protein	-
KPU60_RS15270	57600..58463	-	864	WP_000865436.1	DNA/RNA non-specific endonuclease	-
KPU60_RS15275	58453..58896	-	444	WP_001209505.1	hypothetical protein	-
KPU60_RS15280	58893..59036	-	144	WP_000066155.1	hypothetical protein	-
KPU60_RS15285	59110..60045	-	936	WP_002367766.1	hypothetical protein	-
KPU60_RS15290	60186..60383	-	198	WP_001031355.1	hypothetical protein	-
KPU60_RS16490	60955..61101	+	147	WP_141435800.1	putative holin-like toxin	Toxin
-	61035..61291	-	257	-	-	Antitoxin
KPU60_RS15300	61320..61796	-	477	WP_196008545.1	single-stranded DNA-binding protein	-
KPU60_RS15305	61936..63270	-	1335	WP_002398549.1	PcfJ domain-containing protein	-
KPU60_RS15310	63267..64043	-	777	WP_002398548.1	Cas9 inhibitor AcrIIA9 family protein	-
KPU60_RS15315	64205..64471	-	267	WP_001245899.1	hypothetical protein	-
KPU60_RS15320	64478..64660	-	183	WP_001808764.1	hypothetical protein	-
KPU60_RS15325	65078..65566	-	489	WP_002398545.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	aph(3')-III / ant(6)-Ia / erm(B)	cylI / cylA / cylB / cylM / cylS / cylL / cylR1 / cylR2	1..119713	119713

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-48)

Sequences

Toxin

Protein

• Length: 49 a.a.
• Molecular weight: 5382.49 Da
• Isoelectric Point: 10.6867

>T205790 WP_141435800.1 NZ_CP076489:60955-61101 [Enterococcus faecalis]
MNVLPKSIERRSLLSVSESLQLMLAFGGFTLTLITTIVAILNYKDKKK

Nucleotide

• Length: 147 bp

>T205790 NZ_CP101907:3449918-3450193 [Salmonella enterica subsp. enterica]
ATGGGGCAAAGGAAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGGGCCTGACTGGATTCTTATTGATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin

Nucleotide

• Length: 257 bp

>AT205790 NZ_CP076489:c61291-61035 [Enterococcus faecalis]
CACCGCCACCGCCGTTTAGGCGCGCATGAAAAAAGGTAGGCATTCGCCTACCTTTTCGCACAAAATGTGGTATAATAATT
ATGTAAAGAGGACGTACTGGTAATACGCCCTCATTGATAGCACCGCTAAAGACGGTGGCAGAGTTTTTATAAGTTATTTA
GAAATAACCGGTCTCCTGCTAAAGTGACGGTTATTTCTTTTTGTCTTTATAGTTCAGAATGGCAACAATGGTTGTGATTA
GGGTCAATGTAAACCCA

Structures

Antitoxin