Detailed information of TA system TA205785

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2762874..2763106
• Replicon: chromosome
• Accession: NZ_CP076488
• Organism: Enterococcus faecalis strain UAMS_EL56

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q837V5
• Locus tag: KPU60_RS13570
• Protein ID: WP_002366178.1
• Coordinates: 2762990..2763106 (-)
• Length: 39 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2762874..2763079 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KPU60_RS13550	2758361..2759449	-	1089	WP_002355572.1	diacylglycerol kinase	-
KPU60_RS13555	2759468..2760898	-	1431	WP_002358703.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB	-
KPU60_RS13560	2760898..2762367	-	1470	WP_002361259.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA	-
KPU60_RS13565	2762367..2762672	-	306	WP_002355569.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
KPU60_RS13570	2762990..2763106	-	117	WP_002366178.1	putative holin-like toxin	Toxin
KPU60_RS13575	2763254..2765284	-	2031	WP_002361258.1	NAD-dependent DNA ligase LigA	-
KPU60_RS13580	2765410..2767668	-	2259	WP_002363179.1	DNA helicase PcrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (3-35)

Sequences

Toxin

Protein

• Length: 39 a.a.
• Molecular weight: 4108.01 Da
• Isoelectric Point: 5.9482

>T205785 WP_002366178.1 NZ_CP076488:c2763106-2762990 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFVILALVLDNKNNRS

Nucleotide

• Length: 117 bp

>T205785 NZ_CP101907:c2397353-2397069 [Salmonella enterica subsp. enterica]
ATGACTTATGAACTGGAAATCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin

Nucleotide

• Length: 206 bp

>AT205785 NZ_CP076488:2762874-2763079 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAGTAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAA
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Structures

Toxin

• AlphaFold DB: A0A1G1S9M0

Antitoxin