Detailed information of TA system TA205781

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 580407..580664
• Replicon: chromosome
• Accession: NZ_CP076488
• Organism: Enterococcus faecalis strain UAMS_EL56

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: KPU60_RS02935
• Protein ID: WP_021164441.1
• Coordinates: 580407..580508 (+)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	580457..580664 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KPU60_RS02920	576841..577341	-	501	WP_002378961.1	cysteine hydrolase family protein	-
KPU60_RS02925	577512..579782	+	2271	WP_002399785.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
KPU60_RS02930	579973..580074	+	102	WP_021164442.1	putative holin-like toxin	-
KPU60_RS02935	580407..580508	+	102	WP_021164441.1	putative holin-like toxin	Toxin
-	580457..580664	-	208	-	-	Antitoxin
KPU60_RS02940	580690..581142	-	453	WP_002378959.1	YueI family protein	-
KPU60_RS02945	581327..582274	+	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
KPU60_RS02950	582271..583236	+	966	WP_002387376.1	iron chelate uptake ABC transporter family permease subunit	-
KPU60_RS02955	583233..583988	+	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
KPU60_RS02960	584027..584980	+	954	WP_002370087.1	siderophore ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3598.36 Da
• Isoelectric Point: 6.0656

>T205781 WP_021164441.1 NZ_CP076488:580407-580508 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNNKK

Nucleotide

• Length: 102 bp

>T205781 NZ_CP101907:633528-633812 [Salmonella enterica subsp. enterica]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGCGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAGTGACACGACACAGAAGCTAA

Antitoxin

Nucleotide

• Length: 208 bp

>AT205781 NZ_CP076488:c580664-580457 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAAC
ACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTAT
TTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin