Detailed information of TA system TA205768

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 407954..408285
• Replicon: chromosome
• Accession: NZ_CP076488
• Organism: Enterococcus faecalis strain UAMS_EL56

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: KPU60_RS02125
• Protein ID: WP_277813408.1
• Coordinates: 408142..408285 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	407954..408209 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KPU60_RS02115	403455..403598	-	144	WP_002387585.1	putative holin-like toxin	-
KPU60_RS02120	404194..407952	+	3759	WP_010706868.1	WxL domain-containing protein	-
-	407954..408209	+	256	-	-	Antitoxin
KPU60_RS02125	408142..408285	-	144	WP_277813408.1	type I toxin-antitoxin system toxin PepG1	Toxin
KPU60_RS16485	408518..408592	-	75	Protein_404	type I toxin-antitoxin system toxin	-
KPU60_RS02130	408848..410464	-	1617	WP_002379014.1	phosphatase PAP2/LCP family protein	-
KPU60_RS02135	410926..412221	+	1296	WP_002379013.1	ATP-binding protein	-
KPU60_RS02140	412230..412862	+	633	WP_002358972.1	RloB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5395.58 Da
• Isoelectric Point: 10.8331

>T205768 WP_277813408.1 NZ_CP076488:c408285-408142 [Enterococcus faecalis]
MHVFPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 144 bp

>T205768 NZ_CP101878:c83935-83630 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Nucleotide

• Length: 256 bp

>AT205768 NZ_CP076488:407954-408209 [Enterococcus faecalis]
ATAAAAATGCCCGAGCCTTGAAATAGGAGGCTCAGGCATTTTTTATTGATGGTCTTTTTAGGGTTGTTGTGCTATAATGA
TAAAGAAAAGAGAGATATGCTTCCAACATATCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCAATTTTATTATTTAAA
AATAACCGTGCTTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCAATCAAAGCA
ATGGTAAACATACCAA

Structures

Antitoxin