Detailed information of TA system TA205764

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 403455..403851
• Replicon: chromosome
• Accession: NZ_CP076488
• Organism: Enterococcus faecalis strain UAMS_EL56

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q82Z30
• Locus tag: KPU60_RS02115
• Protein ID: WP_002387585.1
• Coordinates: 403455..403598 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	403709..403851 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KPU60_RS02110	400206..403265	+	3060	WP_002387586.1	WxL domain-containing protein	-
KPU60_RS02115	403455..403598	-	144	WP_002387585.1	putative holin-like toxin	Toxin
-	403709..403851	+	143	-	-	Antitoxin
KPU60_RS02120	404194..407952	+	3759	WP_010706868.1	WxL domain-containing protein	-
KPU60_RS02125	408142..408285	-	144	WP_277813408.1	type I toxin-antitoxin system toxin PepG1	-
KPU60_RS16485	408518..408592	-	75	Protein_404	type I toxin-antitoxin system toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5244.37 Da
• Isoelectric Point: 10.5719

>T205764 WP_002387585.1 NZ_CP076488:c403598-403455 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILKVVKEDKKK

Nucleotide

• Length: 144 bp

>T205764 NZ_CP101877:c4715181-4714897 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Nucleotide

• Length: 143 bp

>AT205764 NZ_CP076488:403709-403851 [Enterococcus faecalis]
TTGTGCTATAATAGCAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCTTT
TTAGTTACAAAAAATAACCGTACTCAGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAA

Structures

Toxin

• AlphaFold DB: A0A059MXV6

Antitoxin