20573

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 917680..918943 Replicon chromosome
Accession NC_002950
Organism Porphyromonas gingivalis W83

Toxin (Protein)


Gene name HipT Uniprot ID Q7MW07
Locus tag PG_RS03780 Protein ID WP_010956143.1
Coordinates 918005..918943 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID Q7MW08
Locus tag PG_RS03775 Protein ID WP_005874041.1
Coordinates 917680..918015 (+) Length 112 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG_RS03750 913013..914094 + 1082 Protein_743 IS5 family transposase -
PG_RS03755 914524..915009 + 486 WP_005874045.1 HU family DNA-binding protein -
PG_RS03760 915046..915828 + 783 WP_004584112.1 DUF4393 domain-containing protein -
PG_RS03765 916330..917235 + 906 WP_005874039.1 hypothetical protein -
PG_RS03770 917459..917683 + 225 WP_005874043.1 helix-turn-helix transcriptional regulator -
PG_RS03775 917680..918015 + 336 WP_005874041.1 HipA N-terminal domain-containing protein Antitoxin
PG_RS03780 918005..918943 + 939 WP_010956143.1 HipA domain-containing protein Toxin
PG_RS03785 919013..919333 + 321 WP_043876418.1 helix-turn-helix domain-containing protein -
PG_RS03790 919387..922869 + 3483 WP_005874047.1 DEAD/DEAH box helicase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(56-280)

Antitoxin

(6-101)


Sequences


Toxin        


Download         Length: 313 a.a.        Molecular weight: 36101.60 Da        Isoelectric Point: 6.1022

>T20573 WP_010956143.1 NC_002950:918005-918943 [Porphyromonas gingivalis W83]
MTNRCLYCYEPLVDGEMDYHAKCCRKLFGTPQAPILPYTSSEVRALADEVVRSQTTVTGVQPKLSLDFDQMSNSPKRFTI
VGLWGRFILKPQTERYSHLPELEDVSMHLAEIAKIETVPHGLMRFSDGELCYITRRIDRTGQGEKLPMEDMCQLSERLTE
YKYKGSHEQVAKLISKYSSVPKLDLVKYWEQVLFSWLIGNADMHLKNYSLYAPEGNEYQLTPAYDLLSTALVIPEDTEEL
ALTLCGKKRKLTRQHFLEAMTASGLDEKVCDNIFARFQHILPEWEACIRQSFLPTEMQRQYIEFILLKFSQI

Download         Length: 939 bp

>T20573 NC_002950:918005-918943 [Porphyromonas gingivalis W83]
ATGACGAATAGATGCCTATACTGCTACGAACCTTTGGTTGATGGAGAGATGGATTACCATGCCAAGTGTTGTCGCAAATT
GTTTGGGACGCCCCAAGCTCCTATATTGCCTTATACAAGTAGCGAAGTACGAGCGTTGGCTGACGAGGTCGTTCGTTCGC
AAACCACAGTGACAGGAGTACAACCCAAGCTATCTCTCGACTTTGACCAAATGAGCAATTCGCCCAAGCGATTTACCATC
GTGGGCTTGTGGGGACGGTTTATTCTTAAACCTCAAACAGAGCGTTATTCGCATCTCCCTGAATTGGAGGATGTGTCAAT
GCACCTTGCAGAGATTGCCAAGATAGAAACAGTTCCTCATGGACTGATGCGATTTAGCGATGGCGAACTATGCTATATCA
CTCGTCGCATAGACCGAACAGGGCAAGGGGAAAAGCTCCCAATGGAAGATATGTGCCAGCTCTCAGAGCGTCTGACCGAA
TATAAATACAAAGGCTCACACGAGCAGGTAGCCAAGCTGATCTCCAAGTATAGCTCTGTGCCAAAACTTGATCTTGTCAA
GTACTGGGAGCAGGTACTCTTTTCGTGGCTGATAGGTAATGCCGATATGCACCTCAAGAATTACTCGCTCTATGCTCCAG
AGGGAAATGAATATCAACTCACTCCAGCTTACGACCTGCTGTCTACGGCACTTGTTATTCCTGAGGATACAGAAGAACTT
GCATTGACCCTCTGTGGCAAAAAGCGCAAACTCACTCGCCAACACTTCCTCGAAGCGATGACAGCCTCAGGACTAGATGA
GAAAGTGTGTGACAATATTTTCGCTCGCTTCCAACACATCCTCCCCGAATGGGAAGCCTGCATCCGTCAGAGCTTCTTAC
CGACAGAGATGCAGAGACAATACATCGAATTTATTCTCCTCAAATTCTCTCAAATCTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12679.49 Da        Isoelectric Point: 4.1551

>AT20573 WP_005874041.1 NC_002950:917680-918015 [Porphyromonas gingivalis W83]
MKQAIVYWKTLKAGILTESDEGYSFAYDKDYLTMPEAQGISLTMPLREEPFQSNMLHPFFDGLIPEGWLLDIAQKNWKID
SRDRMALLLACCRDCIGAVSIEPLNTTEDDE

Download         Length: 336 bp

>AT20573 NC_002950:917680-918015 [Porphyromonas gingivalis W83]
ATGAAACAGGCAATTGTTTATTGGAAGACACTCAAAGCAGGCATTCTCACAGAAAGTGATGAGGGCTATTCCTTTGCTTA
CGACAAGGACTATCTGACTATGCCCGAAGCTCAAGGCATAAGCCTAACAATGCCTTTGCGAGAAGAACCTTTCCAAAGCA
ATATGCTTCATCCATTTTTTGACGGACTTATCCCTGAGGGATGGCTGTTAGATATTGCTCAGAAGAATTGGAAGATAGAC
TCAAGGGATCGAATGGCTTTACTACTGGCTTGTTGCCGAGACTGCATTGGAGCGGTAAGTATCGAACCCCTAAATACGAC
TGAAGATGACGAATAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB Q7MW07


Antitoxin

Source ID Structure
AlphaFold DB Q7MW08

References