Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 917680..918943 Replicon chromosome
Accession NC_002950
Organism Porphyromonas gingivalis W83

Toxin (Protein)


Gene name HipT Uniprot ID Q7MW07
Locus tag PG_RS03780 Protein ID WP_010956143.1
Coordinates 918005..918943 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID Q7MW08
Locus tag PG_RS03775 Protein ID WP_005874041.1
Coordinates 917680..918015 (+) Length 112 a.a.

Genomic Context

PG_RS03750PG_RS03755PG_RS03760PG_RS03765PG_RS03770PG_RS03775PG_RS03780PG_RS03785PG_RS03790
Location: 913013..914094 (1082 bp)
Type: Others
Protein ID: Protein_743
Location: 914524..915009 (486 bp)
Type: Others
Protein ID: WP_005874045.1
Location: 915046..915828 (783 bp)
Type: Others
Protein ID: WP_004584112.1
Location: 916330..917235 (906 bp)
Type: Others
Protein ID: WP_005874039.1
Location: 917459..917683 (225 bp)
Type: Others
Protein ID: WP_005874043.1
Location: 917680..918015 (336 bp)
Type: Antitoxin
Protein ID: WP_005874041.1
Location: 918005..918943 (939 bp)
Type: Toxin
Protein ID: WP_010956143.1
Location: 919013..919333 (321 bp)
Type: Others
Protein ID: WP_043876418.1
Location: 919387..922869 (3483 bp)
Type: Others
Protein ID: WP_005874047.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
PG_RS03750913013..914094+1082Protein_743IS5 family transposase-
PG_RS03755914524..915009+486WP_005874045.1HU family DNA-binding protein-
PG_RS03760915046..915828+783WP_004584112.1DUF4393 domain-containing protein-
PG_RS03765916330..917235+906WP_005874039.1hypothetical protein-
PG_RS03770917459..917683+225WP_005874043.1helix-turn-helix transcriptional regulator-
PG_RS03775917680..918015+336WP_005874041.1HipA N-terminal domain-containing proteinAntitoxin
PG_RS03780918005..918943+939WP_010956143.1HipA domain-containing proteinToxin
PG_RS03785919013..919333+321WP_043876418.1helix-turn-helix domain-containing protein-
PG_RS03790919387..922869+3483WP_005874047.1DEAD/DEAH box helicase family protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-280)

Antitoxin

HipA, N-terminal subdomain 1

(6-101)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36101.60 Da        Isoelectric Point: 6.1022

>T20573 WP_010956143.1 NC_002950:918005-918943 [Porphyromonas gingivalis W83]
MTNRCLYCYEPLVDGEMDYHAKCCRKLFGTPQAPILPYTSSEVRALADEVVRSQTTVTGVQPKLSLDFDQMSNSPKRFTI
VGLWGRFILKPQTERYSHLPELEDVSMHLAEIAKIETVPHGLMRFSDGELCYITRRIDRTGQGEKLPMEDMCQLSERLTE
YKYKGSHEQVAKLISKYSSVPKLDLVKYWEQVLFSWLIGNADMHLKNYSLYAPEGNEYQLTPAYDLLSTALVIPEDTEEL
ALTLCGKKRKLTRQHFLEAMTASGLDEKVCDNIFARFQHILPEWEACIRQSFLPTEMQRQYIEFILLKFSQI

Download         Length: 939 bp

>T20573 NC_002950:918005-918943 [Porphyromonas gingivalis W83]
ATGACGAATAGATGCCTATACTGCTACGAACCTTTGGTTGATGGAGAGATGGATTACCATGCCAAGTGTTGTCGCAAATT
GTTTGGGACGCCCCAAGCTCCTATATTGCCTTATACAAGTAGCGAAGTACGAGCGTTGGCTGACGAGGTCGTTCGTTCGC
AAACCACAGTGACAGGAGTACAACCCAAGCTATCTCTCGACTTTGACCAAATGAGCAATTCGCCCAAGCGATTTACCATC
GTGGGCTTGTGGGGACGGTTTATTCTTAAACCTCAAACAGAGCGTTATTCGCATCTCCCTGAATTGGAGGATGTGTCAAT
GCACCTTGCAGAGATTGCCAAGATAGAAACAGTTCCTCATGGACTGATGCGATTTAGCGATGGCGAACTATGCTATATCA
CTCGTCGCATAGACCGAACAGGGCAAGGGGAAAAGCTCCCAATGGAAGATATGTGCCAGCTCTCAGAGCGTCTGACCGAA
TATAAATACAAAGGCTCACACGAGCAGGTAGCCAAGCTGATCTCCAAGTATAGCTCTGTGCCAAAACTTGATCTTGTCAA
GTACTGGGAGCAGGTACTCTTTTCGTGGCTGATAGGTAATGCCGATATGCACCTCAAGAATTACTCGCTCTATGCTCCAG
AGGGAAATGAATATCAACTCACTCCAGCTTACGACCTGCTGTCTACGGCACTTGTTATTCCTGAGGATACAGAAGAACTT
GCATTGACCCTCTGTGGCAAAAAGCGCAAACTCACTCGCCAACACTTCCTCGAAGCGATGACAGCCTCAGGACTAGATGA
GAAAGTGTGTGACAATATTTTCGCTCGCTTCCAACACATCCTCCCCGAATGGGAAGCCTGCATCCGTCAGAGCTTCTTAC
CGACAGAGATGCAGAGACAATACATCGAATTTATTCTCCTCAAATTCTCTCAAATCTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12679.49 Da        Isoelectric Point: 4.1551

>AT20573 WP_005874041.1 NC_002950:917680-918015 [Porphyromonas gingivalis W83]
MKQAIVYWKTLKAGILTESDEGYSFAYDKDYLTMPEAQGISLTMPLREEPFQSNMLHPFFDGLIPEGWLLDIAQKNWKID
SRDRMALLLACCRDCIGAVSIEPLNTTEDDE

Download         Length: 336 bp

>AT20573 NC_002950:917680-918015 [Porphyromonas gingivalis W83]
ATGAAACAGGCAATTGTTTATTGGAAGACACTCAAAGCAGGCATTCTCACAGAAAGTGATGAGGGCTATTCCTTTGCTTA
CGACAAGGACTATCTGACTATGCCCGAAGCTCAAGGCATAAGCCTAACAATGCCTTTGCGAGAAGAACCTTTCCAAAGCA
ATATGCTTCATCCATTTTTTGACGGACTTATCCCTGAGGGATGGCTGTTAGATATTGCTCAGAAGAATTGGAAGATAGAC
TCAAGGGATCGAATGGCTTTACTACTGGCTTGTTGCCGAGACTGCATTGGAGCGGTAAGTATCGAACCCCTAAATACGAC
TGAAGATGACGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBQ7MW07

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBQ7MW08

References