Detailed information of TA system TA205727

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 2051074..2051296
• Replicon: chromosome
• Accession: NZ_CP076470
• Organism: Escherichia coli strain DH5a

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1E8T8
• Locus tag: KN807_RS09890
• Protein ID: WP_000141634.1
• Coordinates: 2051189..2051296 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	2051074..2051140 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KN807_RS09870	2046515..2047417	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
KN807_RS09875	2047428..2048411	+	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
KN807_RS09880	2048408..2049412	+	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
KN807_RS09885	2049442..2050713	-	1272	WP_001295225.1	aromatic amino acid transport family protein	-
-	2051074..2051140	-	67	-	-	Antitoxin
KN807_RS09890	2051189..2051296	+	108	WP_000141634.1	type I toxin-antitoxin system toxic polypeptide LdrD	Toxin
KN807_RS09895	2051383..2053062	-	1680	WP_000191622.1	cellulose biosynthesis protein BcsG	-
KN807_RS09900	2053059..2053250	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
KN807_RS09905	2053247..2054818	-	1572	WP_001204931.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
KN807_RS09910	2055091..2055279	+	189	WP_001063318.1	cellulose biosynthesis protein BcsR	-
KN807_RS09915	2055315..2056043	+	729	WP_011310329.1	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3916.72 Da
• Isoelectric Point: 9.0157

>T205727 WP_000141634.1 NZ_CP076470:2051189-2051296 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T205727 NZ_CP101858:c4349502-4348960 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin

Nucleotide

• Length: 67 bp

>AT205727 NZ_CP076470:c2051140-2051074 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• PDB: 5LBJ

Antitoxin