Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4916741..4917343 Replicon chromosome
Accession NZ_CP076344
Organism Escherichia coli strain AVS0096

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag KM937_RS23670 Protein ID WP_000897302.1
Coordinates 4916741..4917052 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KM937_RS23675 Protein ID WP_000356397.1
Coordinates 4917053..4917343 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM937_RS23640 (4911771) 4911771..4912556 + 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -
KM937_RS23645 (4912655) 4912655..4913254 + 600 WP_001314324.1 glucose-1-phosphatase -
KM937_RS23650 (4913248) 4913248..4914120 + 873 WP_000920762.1 virulence factor BrkB family protein -
KM937_RS23655 (4914117) 4914117..4914554 + 438 WP_000560978.1 D-aminoacyl-tRNA deacylase -
KM937_RS23660 (4914599) 4914599..4915540 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
KM937_RS23665 (4915604) 4915604..4916512 - 909 WP_001774092.1 alpha/beta hydrolase -
KM937_RS23670 (4916741) 4916741..4917052 + 312 WP_000897302.1 hypothetical protein Toxin
KM937_RS23675 (4917053) 4917053..4917343 + 291 WP_000356397.1 NadS family protein Antitoxin
KM937_RS23680 (4917702) 4917702..4917980 + 279 WP_001296612.1 hypothetical protein -
KM937_RS23685 (4918376) 4918376..4918594 + 219 WP_001314326.1 CopG family transcriptional regulator -
KM937_RS23690 (4918810) 4918810..4919739 - 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
KM937_RS23695 (4919736) 4919736..4920371 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
KM937_RS23700 (4920368) 4920368..4921270 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T205540 WP_000897302.1 NZ_CP076344:4916741-4917052 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

>T205540 NZ_CP101726:2030169-2030271 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT205540 WP_000356397.1 NZ_CP076344:4917053-4917343 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp

>AT205540 NZ_CP101726:c2030278-2030133 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References