Detailed information of TA system TA205537

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 3955739..3956432
• Replicon: chromosome
• Accession: NZ_CP076344
• Organism: Escherichia coli strain AVS0096

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: S1EZG2
• Locus tag: KM937_RS19050
• Protein ID: WP_000415584.1
• Coordinates: 3956136..3956432 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: S1EBV2
• Locus tag: KM937_RS19045
• Protein ID: WP_000650107.1
• Coordinates: 3955739..3956134 (-)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KM937_RS19035 (3951603)	3951603..3953861	-	2259	WP_001281841.1	DNA topoisomerase IV subunit A	-
KM937_RS19040 (3953999)	3953999..3955606	-	1608	WP_001295629.1	ABC transporter substrate-binding protein	-
KM937_RS19045 (3955739)	3955739..3956134	-	396	WP_000650107.1	type II toxin-antitoxin system antitoxin MqsA	Antitoxin
KM937_RS19050 (3956136)	3956136..3956432	-	297	WP_000415584.1	type II toxin-antitoxin system toxin MqsR	Toxin
KM937_RS19055 (3956637)	3956637..3957119	-	483	WP_000183505.1	GyrI-like domain-containing protein	-
KM937_RS19060 (3957172)	3957172..3957564	-	393	WP_000712658.1	OB fold stress tolerance protein YgiW	-
KM937_RS19065 (3957716)	3957716..3958375	+	660	WP_001221493.1	quorum sensing response regulator transcription factor QseB	-
KM937_RS19070 (3958372)	3958372..3959721	+	1350	WP_000673402.1	quorum sensing histidine kinase QseC	-
KM937_RS19075 (3959767)	3959767..3960099	-	333	WP_000917685.1	DUF2645 family protein	-
KM937_RS19080 (3960418)	3960418..3960999	+	582	WP_000065430.1	NADPH:quinone oxidoreductase MdaB	-
KM937_RS19085 (3961030)	3961030..3961344	+	315	WP_000958598.1	putative quinol monooxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3947276..3956432	9156

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Zinc finger, MqsA-type (3-47)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11231.96 Da
• Isoelectric Point: 8.9070

>T205537 WP_000415584.1 NZ_CP076344:c3956432-3956136 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Nucleotide

• Length: 297 bp

>T205537 NZ_CP101726:329181-329549 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14703.10 Da
• Isoelectric Point: 9.2136

>AT205537 WP_000650107.1 NZ_CP076344:c3956134-3955739 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Nucleotide

• Length: 396 bp

>AT205537 NZ_CP101726:328963-329184 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Toxin

• PDB: 3HI2

Antitoxin

• AlphaFold DB: A0A7U9LU65