Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3955739..3956432 Replicon chromosome
Accession NZ_CP076344
Organism Escherichia coli strain AVS0096

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag KM937_RS19050 Protein ID WP_000415584.1
Coordinates 3956136..3956432 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KM937_RS19045 Protein ID WP_000650107.1
Coordinates 3955739..3956134 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM937_RS19035 (3951603) 3951603..3953861 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
KM937_RS19040 (3953999) 3953999..3955606 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
KM937_RS19045 (3955739) 3955739..3956134 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KM937_RS19050 (3956136) 3956136..3956432 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
KM937_RS19055 (3956637) 3956637..3957119 - 483 WP_000183505.1 GyrI-like domain-containing protein -
KM937_RS19060 (3957172) 3957172..3957564 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
KM937_RS19065 (3957716) 3957716..3958375 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
KM937_RS19070 (3958372) 3958372..3959721 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
KM937_RS19075 (3959767) 3959767..3960099 - 333 WP_000917685.1 DUF2645 family protein -
KM937_RS19080 (3960418) 3960418..3960999 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
KM937_RS19085 (3961030) 3961030..3961344 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3947276..3956432 9156


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T205537 WP_000415584.1 NZ_CP076344:c3956432-3956136 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T205537 NZ_CP101726:329181-329549 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT205537 WP_000650107.1 NZ_CP076344:c3956134-3955739 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT205537 NZ_CP101726:328963-329184 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References