Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 691544..691802 Replicon chromosome
Accession NZ_CP076344
Organism Escherichia coli strain AVS0096

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag KM937_RS03330 Protein ID WP_000809168.1
Coordinates 691544..691696 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 691745..691802 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM937_RS03310 686789..687502 - 714 WP_001102391.1 acidic protein MsyB -
KM937_RS03315 687528..687932 - 405 WP_000843687.1 DUF2541 family protein -
KM937_RS03320 688304..690220 + 1917 WP_000516135.1 molecular chaperone DnaK -
KM937_RS03325 690309..691439 + 1131 WP_001118464.1 molecular chaperone DnaJ -
KM937_RS03330 691544..691696 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 691745..691802 + 58 - - Antitoxin
KM937_RS03335 692311..693072 + 762 WP_001274832.1 outer membrane protein OmpK -
KM937_RS03340 693092..694585 + 1494 WP_001774152.1 sulfatase-like hydrolase/transferase -
KM937_RS03345 694714..695973 + 1260 WP_000494929.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T205519 WP_000809168.1 NZ_CP076344:c691696-691544 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T205519 NZ_CP101705:1911104-1911355 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 58 bp

>AT205519 NZ_CP076344:691745-691802 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References