Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2518226..2518919 Replicon chromosome
Accession NZ_CP076318
Organism Escherichia coli strain Survcare045

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag KNN08_RS13710 Protein ID WP_000415584.1
Coordinates 2518623..2518919 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KNN08_RS13705 Protein ID WP_000650107.1
Coordinates 2518226..2518621 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KNN08_RS13695 (2514090) 2514090..2516348 - 2259 WP_032329482.1 DNA topoisomerase IV subunit A -
KNN08_RS13700 (2516486) 2516486..2518093 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
KNN08_RS13705 (2518226) 2518226..2518621 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KNN08_RS13710 (2518623) 2518623..2518919 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
KNN08_RS13715 (2519124) 2519124..2519606 - 483 WP_000183505.1 GyrI-like domain-containing protein -
KNN08_RS13720 (2519659) 2519659..2520051 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
KNN08_RS13725 (2520203) 2520203..2520862 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
KNN08_RS13730 (2520859) 2520859..2522208 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
KNN08_RS13735 (2522254) 2522254..2522586 - 333 WP_000917685.1 DUF2645 family protein -
KNN08_RS13740 (2522905) 2522905..2523486 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
KNN08_RS13745 (2523517) 2523517..2523831 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T205503 WP_000415584.1 NZ_CP076318:c2518919-2518623 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T205503 NZ_CP101703:c4819984-4819850 [Xanthomonas oryzae pv. oryzae]
ATGAAGCGTGCAATTGTGCTGCTCGTGCTGTCCATGTTGTCGGTCGGTCTGCTGTCGGGCTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGAAGGGCGCCGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT205503 WP_000650107.1 NZ_CP076318:c2518621-2518226 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT205503 NZ_CP101703:c4820200-4820048 [Xanthomonas oryzae pv. oryzae]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCTGGCGC
TGGCAAGGACTTGCAGGGCGCGGGTGGGAAGGTCGAGAAAACGGCCGAAAAATGCAGCGATGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References